Diet & Lifestyle

How to Naturally Influence Metabolism

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How to Naturally Influence Metabolism

Last updated: April 8th, 2021

The term metabolism is often associated with weight management. Having a “fast metabolism” is often used to describe individuals who seem to lose weight easily, while having a “slow metabolism” is used to describe individuals who have difficulty losing weight.

Metabolism does play a role in weight loss and management; however, metabolism is also closely connected to almost every aspect of health. Changes in metabolic pathways in the body are associated with many health issues, ranging from gout and cardiovascular disorders to cancer. Understanding the factors that affect metabolism can help you to lose weight, prevent the risk of certain diseases, and optimize your overall metabolic health. (3)(18)

What is metabolism?

Metabolism describes all of the processes in the body that consume or produce energy, which generally involves the use of the nutrients glucose (sugar), fatty acids, and amino acids. These nutrients are used in metabolic pathways that maintain energy balance and produce or store molecules containing energy. (3)

A metabolic pathway is a series of chemical reactions that occur in a cell. There are three primary metabolic pathways, including:

  • Anabolic pathways, which combine simple molecules to form more complex molecules
  • Catabolic pathways, which break down molecules to release energy
  • Elimination pathways, which dispose of the toxic waste produced by the first two pathways (3)

For example, glycogenesis is an anabolic process that stores glucose, a simple sugar molecule, in the liver and muscles as glycogen, a more complex molecule. Glycolysis is a catabolic process that breaks down glucose for energy. (3)

Factors that affect metabolism

The proper functioning of these different metabolic pathways is essential to life as they are responsible for nutrient use and energy production in the body. (3) Lifestyle factors, such as poor dietary and exercise habits, can impact metabolism and potentially contribute to metabolic dysfunctions, such as those seen in metabolic syndrome and obesity. (18)

Did you know? Worldwide, an estimated 1.4 billion adults and 200 million children are overweight or obese. (11)

Metabolic disorders

There are various metabolic disorders, which involve disruptions to metabolic pathways. For example, mitochondrial diseases affect a part of cells known as mitochondria, the organelles that produce energy. Certain metabolic disorders occur when an organ becomes diseased, such as the pancreas in diabetes. (20) Inherited metabolic disorders, referred to as inborn errors of metabolism (IEMs), include approximately 500 rare diseases, many of which involve genetic mutations to enzymes and transporters involved in different metabolic processes. (3)

Metabolic syndrome

Metabolic syndrome, sometimes referred to as syndrome X or insulin resistance, is a condition characterized by various metabolic changes, such as insulin resistance, abdominal obesity, hypertension (high blood pressure), and hyperlipidemia (elevated blood level of lipids). Having metabolic syndrome increases your risk of conditions such as coronary diseases, stroke, and type 2 diabetes. (18)


People exercising
Regular physical activity has been associated with beneficial metabolic changes.


Assessing metabolism

Several methods are used to assess individual metabolism and metabolic health, as well as to help diagnose and manage metabolic disorders.

Basal metabolic rate

Basal metabolic rate (BMR) is the amount of energy your body requires to carry out its vital functions at rest, such as respiration and organ function. BMR is considered to be the largest contributor to your total energy expenditure (i.e., calories used) and is often used to determine calorie intake goals in weight loss interventions. (17)

An individual’s basal metabolic rate can be determined using direct or indirect calorimetry. Direct calorimetry, considered the gold standard for measuring basal metabolic rate, involves directly measuring heat exchange between the body and the environment, which indicates the amount of energy used during metabolism. (8) Indirect calorimetry uses a device that measures the amount of oxygen used and carbon dioxide released by the body, which indicates energy expenditure and the amount of each nutrient used for energy. (6)

BMR measurement is typically done under strict requirements, including being free from stress, abstaining from exercise for 24 hours, fasting overnight, and being fully rested. (12) BMR measurement devices are not always accessible, and basal metabolic rate calculations are commonly used as an alternative. (6)

Basal metabolic rate calculator

Basal metabolic rate calculators use various equations to estimate an individual’s basal metabolic rate without using a BMR measurement device. Still widely used today, the Harris-Benedict equations were published in 1919 and provide the basis for many equations that have since been developed. (6)(17)

Basal metabolic rate calculator equations consider individual factors that will affect BMR, such as:

  • Age
  • Body composition (i.e., fat mass, fat-free mass)
  • Height
  • Race
  • Sex
  • Weight (17)

Resting metabolic rate

Resting metabolic rate, also called resting energy expenditure, refers to the body’s energy requirement in a resting position (i.e., during a non-exercise state). Resting metabolic rate, sometimes confused with BMR, is tested under less strict requirements than BMR. For example, an RMR measurement requires an individual to abstain from exercise for 12 hours prior to the test. (12)

Indirect calorimetry, mentioned above, is also used to measure resting metabolic rate. Assessing resting metabolic rate may be beneficial for individualized dietary planning in managing conditions such as diabetes and obesity. (6)


Doctor conducting tests
Direct and indirect calorimetry are tests used to determine metabolic rate.


Comprehensive metabolic panel

A comprehensive metabolic panel (CMP) is a blood test used to assess functions and processes in the body, such as:

The CMP measures 14 substances in the blood that are involved in metabolic processes, including certain minerals, proteins, enzymes, and waste products. Your healthcare practitioner may order a comprehensive metabolic panel as part of a routine checkup, to monitor medication side effects, or if a metabolic condition such as diabetes, kidney failure, or liver disease is suspected. (21)

Basic metabolic panel

A basic metabolic panel (BMP) is similar to the CMP but does not include the protein and liver tests. Depending on your health history and status, your healthcare practitioner may select either a comprehensive metabolic panel or a basic metabolic panel. (21)

Metabolism and weight

There are numerous perspectives on what causes weight gain and obesity. One school of thought, the conventional model of obesity, states that when energy intake (i.e., calories consumed) exceeds energy expenditure, weight gain occurs. (10)(17) As a result, a long-term imbalance between energy intake and expenditure can lead to obesity. (1)(17) This assumption has led to many weight loss approaches based on the directive to eat less and move more, known as the “energy balance” or “calories in, calories out” theory of weight loss. (10)

Another school of thought, the carbohydrate-insulin model of obesity, suggests that a decrease in dietary quality over the last 50 years has contributed to the increasing prevalence of overweight and obesity. According to this theory, consuming a diet high in processed carbohydrates leads to hormonal changes that increase hunger and calorie storage in adipose (fat) tissue and decrease energy expenditure. Based on the carbohydrate-insulin model of obesity, weight loss approaches should focus less on the quantity of calories consumed and more on diet quality by reducing the intake of processed carbohydrates. (10)

Having a fast metabolism vs. a slow metabolism: does it affect your weight?

One study in 757 adults examined whether individuals with a low BMR (considered a slow metabolism) are more likely to gain weight than individuals with a high BMR (considered a fast metabolism). The difference in BMR between the two groups was an average of 500 calories per day. After three or more years, the low-BMR group did not have greater body weight change than the high-BMR group, which suggests that individuals with slow metabolism are not necessarily predisposed to gain weight. (1)

The researchers propose that lifestyle factors, such as dietary changes, medications, and exercise programs, influence weight more than an individual’s basal metabolic rate. However, other studies with conflicting results have found that basal metabolic rate and 24-hour energy expenditure do predispose an individual to gain weight. (1) In the end, certain lifestyle modifications may be used to both increase metabolism and manage weight.

How to increase metabolism

Certain dietary and lifestyle changes can support your metabolism. For example, research has examined foods that increase metabolism by increasing thermogenesis, a process in the body that converts energy to heat. Components found in these foods may regulate the activation of certain fat cells, increase thermogenesis, and improve metabolism, thereby helping to prevent metabolic conditions such as diabetes and obesity. (15) Other lifestyle factors that can help support metabolism include overall dietary patterns, physical activity, sleep, and supplementation.

Eat red peppers and chili peppers

Capsaicin, found in hot chili peppers, and capsinoids, found in non-pungent red peppers, are active components that have been found to increase energy expenditure and fat oxidation (the use of fat for energy). (15)

Drink green tea

Catechins, compounds found in green tea, have been associated with weight loss, changes in fat metabolism, and increased energy expenditure. While it’s unclear if green tea specifically increases thermogenesis, a meta-analysis of clinical studies found that regular green tea intake decreased body weight and prevented weight regain. (15)

Follow a high-protein diet

High-protein diets have been associated with reducing body weight, improving body composition (i.e., reducing fat mass while preserving fat-free mass), as well as maintaining weight loss in studies of up to twelve months. These effects may be due to metabolic changes in the body, such as increased resting metabolic rate and diet-induced thermogenesis, which refers to the amount of energy used during nutrient absorption, metabolism, and storage. (13)

Choose low-glycemic carbohydrates

According to the carbohydrate-insulin model of obesity, a low-glycemic load diet may result in greater weight loss than calorie restriction. Glycemic load is a measure that indicates how different foods affect blood glucose levels after their consumption. A high-glycemic load diet, including a high intake of sugar, refined grains, and potatoes, results in several metabolic changes that may slow metabolic rate and lead to weight gain, such as increased insulin levels and calorie storage in fat cells. (10)

To decrease the glycemic load of your diet, minimize your intake of processed and refined carbohydrates. Choose low-glycemic carbohydrates, such as:

  • Legumes (e.g., beans, lentils, peas)
  • Non-starchy vegetables (e.g., asparagus, broccoli, cucumber, leafy greens, zucchini)
  • Whole fruits (i.e., rather than dried fruit, fruit juices, or fruit syrups)
  • Whole grains (i.e., grains with the bran and germ intact) (10)


Whole grain vs. refined grain
Whole grains are rich in fiber, vitamins, and minerals.


Stay hydrated

A study that examined the effects of water consumption on body composition and weight in overweight women found that increasing water intake was associated with weight loss and decreased fat mass, independent of diet and physical activity. (19) Consuming 16 oz (500 ml) of water prior to a meal may reduce your intake of calories during a meal and support weight loss efforts. (4)

Get active

Having a sedentary lifestyle can increase your risk of metabolic syndrome, diabetes, and obesity. (2)(18) On the other hand, regular physical activity has been associated with beneficial metabolic changes, such as increasing the number of mitochondria in muscle fibers, reversing insulin resistance in muscles, and reducing fat production in the liver following a meal. (18)

A type of exercise known as high-intensity interval training (HIIT) has been shown to support metabolism by increasing cardiovascular and muscle adaptation, changes that increase the body’s physical capacity and efficiency. HIIT programs involve short bursts of high-intensity activity, typically aerobic exercises, with periods of rest or low-intensity exercise. (5)

Did you know? According to the Centers for Disease Control and Prevention, 38% of U.S. adults with diabetes get less than ten minutes per week of vigorous or moderate activity during each activity category of work, transportation, and leisure time. (2)

Get enough sleep

Sleep plays an important role in energy metabolism, and sleep deprivation has been associated with an increased risk of weight gain and obesity. One trial assessed the effects of five days of insufficient sleep on energy intake and expenditure. The study found that sleeping for only five hours per night was associated with increased food intake and weight gain, while sleeping for nine hours per night was associated with decreased food intake, particularly sources of fats and carbohydrates, and slight weight loss. (11)


Woman taking supplements
Certain dietary supplements may improve metabolic markers, such as products containing fish oil, resveratrol, and B vitamins.


Consider supplementation

Fish oil supplements, a source of omega-3 fatty acids, have been shown to improve metabolic markers such as blood lipid levels, energy expenditure, and glucose levels. (15) The polyphenol resveratrol, a compound found in grape skins and red wine, may increase thermogenesis and cellular respiration, a metabolic process that converts energy from food into energy used by cells in the body. However, clinical trials of resveratrol supplementation are needed to determine these effects in humans. (15)

Lastly, B vitamins play important roles in energy metabolism, including the release of energy from foods and the metabolism of carbohydrates, fats, and proteins. (7) Low levels of vitamin B9 (folic acid) and B12 (cobalamin) have been found in individuals with metabolic syndrome, (14) and studies in individuals with metabolic syndrome suggest that vitamin B3 (niacin) and B12 supplementation may improve metabolic markers such as blood lipid levels. (16) If you’re a patient, consult your integrative healthcare practitioner before supplementation.

The bottom line

Metabolism involves various processes in the body that include anabolic, catabolic, and elimination pathways. (3) A healthy metabolism is essential for energy production, energy balance, (3) weight management, and prevention of conditions such as metabolic syndrome and obesity. (18) Follow the tips in this article to help optimize your metabolic health.

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  1. Anthanont, P., & Jensen, M. D. (2016). Does basal metabolic rate predict weight gain? The American Journal of Clinical Nutrition, 104(4), 959–963.
  2. Centers for Disease Control and Prevention. (2020, September 28). National Diabetes Statistics Report, 2020.
  3. DeBerardinis, R. J., & Thompson, C. B. (2012). Cellular metabolism and disease: What do metabolic outliers teach us? Cell, 148(6), 1132–1144.
  4. Dennis, E. A., Dengo, A. L., Comber, D. L., Flack, K. D., Savla, J., Davy, K. P., & Davy, B. M. (2010). Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults. Obesity, 18(2), 300–307.
  5. Gibala, M. J., Little, J. P., Macdonald, M. J., & Hawley, J. A. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology, 590(5), 1077–1084.
  6. Gupta, R. D., Ramachandran, R., Venkatesan, P., Anoop, S., Joseph, M., & Thomas, N. (2017). Indirect calorimetry: From bench to bedside. Indian Journal of Endocrinology and Metabolism, 21(4), 594–599.
  7. Huskisson, E., Maggini, S., & Ruf, M. (2007). The role of vitamins and minerals in energy metabolism and well-being. The Journal of International Medical Research, 35(3), 277–289.
  8. Kenny, G. P., Notley, S. R., & Gagnon, D. (2017). Direct calorimetry: A brief historical review of its use in the study of human metabolism and thermoregulation. European Journal of Applied Physiology, 117(9), 1765–1785.
  9. Linus Pauling. (2014, April 28). Whole Grains. Oregon State University.
  10. Ludwig, D. S., & Ebbeling, C. B. (2018). The carbohydrate-insulin model of obesity: Beyond “calories in, calories out.” JAMA Internal Medicine, 178(8), 1098–1103.
  11. Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P., Jr. (2013). Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5695–5700.
  12. McMurray, R. G., Soares, J., Caspersen, C. J., & McCurdy, T. (2014). Examining variations of resting metabolic rate of adults: a public health perspective. Medicine and Science in Sports and Exercise, 46(7), 1352–1358.
  13. Moon, J., & Koh, G. (2020). Clinical evidence and mechanisms of high-protein diet-induced weight loss. Journal of Obesity & Metabolic Syndrome, 29(3), 166–173.
  14. Narang, M., Singh, M., & Dange, S. (2016). Serum homocysteine, vitamin B12 and folic acid levels in patients with metabolic syndrome. The Journal of the Association of Physicians of India, 64(7), 22–26.
  15. Okla, M., Kim, J., Koehler, K., & Chung, S. (2017). Dietary factors promoting brown and beige fat development and thermogenesis. Advances in Nutrition, 8(3), 473–483.
  16. Patti, A. M., Al-Rasadi, K., Giglio, R. V., Nikolic, D., Mannina, C., Castellino, G., … & Toth, P. P. (2018). Natural approaches in metabolic syndrome management. Archives of Medical Science, 14(2), 422–441.
  17. Sabounchi, N. S., Rahmandad, H., & Ammerman, A. (2013). Best-fitting prediction equations for basal metabolic rate: Informing obesity interventions in diverse populations. International Journal of Obesity, 37(10), 1364–1370.
  18. Saklayen, M. G. (2018). The global epidemic of the metabolic syndrome. Current Hypertension Reports, 20(2), 12.
  19. Stookey, J. D., Constant, F., Popkin, B. M., & Gardner, C. D. (2008). Drinking water is associated with weight loss in overweight dieting women independent of diet and activity. Obesity, 16(11), 2481–2488.
  20. U.S. National Library of Medicine. (2019, November 5). Metabolic disorders. MedlinePlus.
  21. U.S. National Library of Medicine. (2020, December 10). Comprehensive metabolic panel (CMP). MedlinePlus.


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