When it comes to hormones, testosterone, estrogen, and cortisol seem to get all the attention. But there’s another hormone that’s critical to good health—dehydroepiandrosterone, more commonly known as DHEA. Often considered an anti-aging hormone, DHEA is a popular supplement among athletes and bodybuilders because it is thought by some to increase performance and muscle strength. (5) But does DHEA really live up to the hype? Or does it provide other, lesser known benefits? Let’s take a deeper dive into what the science actually says about this key hormone.


Medical checklist
Although DHEA is a weak hormone, it plays an important role in human health.


What is DHEA?

DHEA is a hormone that’s made primarily in the small triangular glands that sit on top of your kidneys known as the adrenal glands. (28) Smaller amounts of DHEA are produced in the brain and the gonads, which reproductive glands found in a man’s testes or a woman’s ovaries. (4)

Once produced, most of the DHEA circulating in the bloodstream is in the form of DHEA sulfate (DHEAS). Together, DHEA and DHEAS are the most abundant steroid hormones in the body. (15) Although it’s role isn’t fully understood, scientists do know that some of the DHEA produced by the body is converted to testosterone and a form of estrogen called estradiol. (4)

Even though DHEA is abundant when you’re young, production peaks around the age of 30 and declines throughout the remainder of your life. (1) In fact, it’s estimated that DHEA levels can drop by as much as 90% over the course of a lifetime. (24) That has led some people to supplement with DHEA in hopes of reversing this hormonal decline and its effects on aging.

Did you know? Scientists didn’t make the connection between waning DHEAS levels and aging until 1965, noting that the hormone declined in a linear fashion as people grew older. (19)

DHEA benefits

While science doesn’t support the premise that taking DHEA supplements boosts athletic performance or muscle mass, studies do report several significant health benefits.

Bone health

Bone loss is a very common health concern as we grow older. As a result, about one-quarter of all women and about 5% of all men over the age of 65 develop osteoporosis. (17) Some studies suggest that supplementing with DHEA may improve bone mineral density and reduce the risk of osteoporosis by increasing bone-forming osteoblasts as well as insulin-like growth factor 1 (IGF-1) activity. IGF-1 helps promote healthy bone development. (11)(14)

In one placebo-controlled study of 140 men and women between the ages of 60 and 88, researchers from the University of Colorado at Denver found that both the men and women taking 50 mg of DHEA for 12 months experienced improvements in their hip bone mineral density. The researchers noted that DHEA supplementation also increased spinal bone mineral density in the women. (9)

Another year-long trial involving 225 healthy adults aged 55 to 88 reported that supplementing with a daily dose of DHEA improved lumbar spine bone mineral density and reduced bone resorption in the women, but not the men. What’s more, this particular study also noted no benefits for hip, femoral neck, or total bone mineral density in either sex. (26)


Woman sitting on a couch browsing on her phone.
Studies show that DHEA can help reduce the symptoms of depression by as much as 50%.



DHEA may also help alleviate symptoms in those suffering from mild to moderate depression. A review of 22 studies that was published in the journal Current Drug Targets found that DHEA supplementation resulted in improving the symptoms of depression in those with mild depression and among those who were resistant to conventional therapy. (18)

Similar results were found in people with major depression, according to a crossover study conducted by the National Institute of Mental Health. During the study, 46 patients with short- and long-term major depression were given either supplemental DHEA or a placebo for six weeks. After a brief washout period, the groups switched for another six weeks. The majority of participants experienced a 50% reduction in their symptoms when taking the DHEA supplements compared to when taking the placebo. (25)


There’s some evidence that supplementing with DHEA may help modulate immunity. (7)(20) One small study of men with an average age of 63 found that taking 50 mg of supplemental DHEA daily activated the immune system, possibly by enhancing IGF-1 levels by as much as 20%. While IGF-1 plays a role in bone health, it also stimulates important immune cells, such as regulatory T-cells and natural killer (NK) cells. (10)


Man and woman hugging
DHEA may help to improve many aspects of female sexual health.


Reproductive health

Because DHEA is a precursor to testosterone and estrogen, it makes sense that it would play a role in improving sexual and reproductive health, especially as we age. However, these benefits are more pronounced in women than in men.

Even though DHEA is a precursor to testosterone, studies on its ability to improve sexual function in men are mixed. Early research suggests that supplementing with DHEA may improve erectile dysfunction. (22) However, more recent studies report that supplementing with this testosterone precursor doesn’t appear to improve sexual problems in men. (16)(27)

On the other hand, supplementing with DHEA can improve women’s sexual health. One small double-blind study of 24 women with adrenal insufficiency found that those who took 50 mg of DHEA daily experienced an increase in libido and sexual satisfaction. The most pronounced improvement was seen after four months of supplementation. (2)

DHEA may help to improve a woman’s sexual function in other ways as well. An observational study of 50 premenopausal women published in the journal Endocrine found that supplementing with DHEA not only increased serum androgen levels, it also improved overall sexual function. All of the women taking part in the study completed a Female Sexual Function Index (FSFI) questionnaire at the beginning of the study and again at four and eight weeks after starting supplementation. By the end of the study, the researchers found that, on average, desire increased by 17%, arousal was enhanced by 12%, and vaginal lubrication improved by 8%. What’s more, those who began the study with the lowest FSFI scores experienced 54% more orgasms, were 24% more satisfied, and had 25% less pain during sex. (12)

Did you know? Supplementing with DHEA may improve pregnancy odds in women with poor ovarian function or among those undergoing in vitro fertilization (IVF). (6)(29)

DHEA dosage

Although studies use dosages ranging from 25 mg to 200 mg, the recommended oral dose of DHEA in most people is 25 mg to 50 mg. It’s also best to take your DHEA supplement at bedtime since this mimics the body’s natural rise of the hormone during sleep. (23)

Did you know? Exercise can naturally increase DHEA production in older women. (8)

DHEA side effects

DHEA supplements have been safely used in studies for up to 12 months. (13) However, side effects can occur and include:

  • Abnormal hair growth (5)
  • Acne (5)
  • Breast pain and development in men (3)
  • Changes to menstrual cycle (5)
  • Decrease in HDL (good) cholesterol levels (21)
  • Deepening of the voice (5)
  • Upset stomach (5)

DHEA supplements can interact with a number of prescription medications, including antidepressants, insulin, and anti-clotting pharmaceutical medications. (5)

The bottom line

DHEA is generally safe and may benefit older adults and those with certain health concerns such as bone loss, depression, or sexual dysfunction. Be sure to speak to your integrative healthcare provider before taking a new supplement to ensure it’s right for you.

Fullscript simplifies supplement dispensing

Create your dispensary today I'm a patient
  1. Arit, W. (2004). Dehydroepiandrosterone and ageing. Best Practices and Research. Clinical Endocrinology and Metabolism, 18(3), 363-380.
  2. Arit, W., Callies, F., van Vijmen, J.C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., … Allolio, B. (1999). Dehydroepiandrosterone replacement in women with adrenal insufficiency. New England Journal of Medicine, 341(14), 1013-1020.
  3. Brown, G.A., Vukovich, M.D., Sharp, R.L., Reifenrath, T.A., Parsons, K.A. & King, D.S. (1999). Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. Journal of Applied Physiology, 87(6), 2274-2283.
  4. Celec, P. & Stárka, L. (2003). Dehydroepiandrosterone—Is the fountain of youth drying out? Physiological Research, 52, 397-407.
  5. DHEA. (2020). MedlinePlus. National Institutes of Health. https://medlineplus.gov/druginfo/natural/331.html
  6. Fusi, F.M., Ferrario, M., Bosisio, C., Arnoldi, M., & Zanga, L. (2013). DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function. Gynecological Endocrinology, 29(10), 940-943.
  7. Hazeldine, J., Arit, W., & Lord, J.M. (2010). Dehydroepiandrosterone as a regulator of immune cell function. The Journal of Steroid Biochemistry and Molecular Biology, 120(2-3), 127-136.
  8. Heaney, J.L.J., Carroll, D., & Phillips, A.C. (2013). DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex. Age (Dordrecht, Netherlands), 35(2), 395-405.
  9. Jankowski, C.M., Gozansky, W.S., Schwartz, R.S.,Dahl, D.J., Kittelson, J.M., & Scott, S.M. (2006). Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: A randomized, controlled trial. The Journal of Clinical Endocrinology & Metabolism, 91(8), 2986-2993.
  10. Khorram, O., Vu, L., & Yen, S.S.C. (1997). Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. Journal of Gerontology: Medical Sciences, 52(1), M1:7.
  11. Kirby, D.J., Buchalter, D.B., Anil, U., & Leucht, P. (2020). DHEA in bone: the role in osteoporosis and fracture healing. Archives of Osteoporosis, 15, 84.
  12. Kushnir, V.A., Darmon, S.K., Barad, D.H., Weghofer, A., & Gleicher, N. (2019). Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women. Endocrine, 63(3), 632-638.
  13. Lasco a., Frisina, N., Morabito, N., Gaudio, A., Morini, E., Trifiletti, A., Basile, G., … Cucinotta, D. (2001). Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. European Journal of Endocrinology, 145(4), 457-461.
  14. Lin, H., Li, L., Wang, Q., Wang, Y., Wang, J., & Long, X. (2019). A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA supplementation of bone mineral density in healthy adults. Gynecological Endrocrinology, 35,(11), 924-931.
  15. Maninger, N.l, Wolkowitz, O.M., Reus, V.I., Eel, E.S., & Mellon, S.H. (2009). Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Frontiers in Neuroendrocrinology, 30(1), 65-91.
  16. Morales, A., Black, A., Emerson, L., Barkin, J., Kuzmarov, I., & Day, A. (2009). Androgens and sexual function: a placebo-controlled, randomized, double-blind study of testosterone vs. dehydroepiandrosterone in men with sexual dysfunction and androgen deficiency. Aging Male, 12(4), 104-112.
  17. Osteoporosis. (2020). Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/fastats/osteoporosis.htm
  18. Peixoto, C., Cheda, J.N.D., Nardi, A.E., Veras, A.B., & Cardoso, A. (2014). The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review. Current Drug Targets, 15(9), 901-914.
  19. Pope, J.E., Cupp, M.J., & Tracy, T.S. (2003) Dehydroepiandrosterone (DHEA) (Prasterone). In: Dietary Supplements. Forensic Science and Medicine. Humana Press, Totowa, NJ.
  20. Prall, S.P. & Muehlenbein, M.P. (2018). Chapter Four—DHEA modulates immune function: A review of evidence. Vitamins and Hormones, 108, 125-144.
  21. Qin, Y., Santos, H.O., Khani, V., Tan, S.C., & Zhi, Y. (2020). Effects of dehydroepiandrosterone (DHEA) supplementation on the lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases, 30(9), 1465-1475.
  22. Reiter, W.J., Pycha, A., Schatzi, G., Pokorneyy, A., Grber, D.M., Huber, J.C., & Marberger, M. (1999). Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study. Urology, 53(3), 590-594.
  23. Rutkowski, K., Sowa, P., Rutkowska-Talipska, J., Kuryliszyn-Moskal, A., & Rutkowski, R. (2014). Dehydroepiandrosterone (DHEA): hypes and hopes. Drugs, 74(11), 1195-1207.
  24. Samaras, N., Samaras, D., Frangos, E., Forster, A., & Philippe, J. (2013). A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: Is treatment beneficial? Rejuvenation Research, 16(4), 285-294.
  25. Schmidt, P.J., Daly, R.C., Bloch, M., Smith, M.J., Danaceau, M.A., Simpson St. Clair, L., Murphy, J.H., Haq, N., & Rubinow, D.R. (2005). Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Archives of General Psychiatry, 62 (2), 154-162.
  26. von Mühlen, D., Laughlin, G.A., Kritz-Silverstein, D., Bergstrom, J., & Bettencourt, R. (2008). Effect of dehydroepiandrosterone supplementation on bone mineral density bone markers, and bone composition in older adults: the DAWN trial. Osteoporosis International, 19(5), 699-707.
  27. Walther, A. & Seuffert, J. (2020). Testosterone and dehydroepiandrosterone treatment in ageing men: are we all set? The World Journal of Men’s Health, 38(2), 178-190.
  28. Webb, S.J., Georghegan, T.E., & Prough, R.A. (2006). The biological actions of dehydroepiandrosterone involves multiple receptors. Drug Metabolism Reviews, 38(102), 89-116.
  29. Xu, L., Hu, C., & Li, Y. (2019). The effect of dehydroepiandrosterone (DHEA) supplementation on IVF or ICSI: a meta-analysis of randomized controlled trials. Geburtshilfe Frauenheikd, 79(7), 705-712.