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Influencer Protocol

The Functional Medicine Approach to Immune Support: Virus-Specific Nutraceutical and Botanical Agents

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The Functional Medicine Approach to Immune Support: Virus-Specific Nutraceutical and Botanical Agents

Disclaimer

The Fullscript Integrative Medical Advisory team adapted the original version of this template developed by the Institute for Functional Medicine to accommodate quick upload into your Fullscript account. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

Note: products included in the protocol are the most commonly recommended by ingredient category and can be modified to the practitioner’s preference.

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Ingredient Overview

Ingredient Dosing Benefits
Curcumin 500-1,000 mg, 2x daily
  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
Quercetin Regular: 1,000 mg orally, 2x daily

Phytosome: 500 mg, 2x daily

  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
Zinc 30-60 mg orally daily, in divided doses
  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
N-Acetylcysteine (NAC) 600-900 mg, 2x daily
  • Enhances the immune system
  • Reduces symptoms
Vitamin D 5,000 IU orally, daily
  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
Vitamin A 10,000-25,000 IU, daily
  • Enhances the immune system
  • Reduces symptoms
Vitamin C 1-3 g orally, daily
  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
Melatonin 5-20 mg, taken at bedtime
  • Enhances the immune system
  • Decreases viral growth
Elderberry (Sambucus nigra) 500 mg orally, daily
  • Enhances the immune system
  • Decreases viral growth
Palmitoylethanolamide (PEA) 300 mg orally, 2x daily (prevention); 600-900 mg, 3x daily for 2 weeks (treatment)
  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
Epigallocatechin gallate (EGCG) 4 cups daily (green tea) 225 mg orally, daily (EGCG)
  • Enhances the immune system
  • Decreases viral growth
  • Reduces symptoms
Resveratrol 100-150 mg orally, 2x daily
  • Enhances the immune system
  • Decrease viral growth

Curcumin

Dosing: 500-1,000 mg, 2x daily

Benefits:

  • Curcumin has been shown to reduce inflammation and decrease viral activity
  • Enhances the immune system
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action:

Favorably modulate viral-induced pathological cellular processes:

  • Modulation of NLRP3 inflammasome activation[5],[19],[20],[21]
Curcumin in the Fullscript catalog

Quercetin

Dosing:

  • Regular: 1,000 mg orally, 2x daily
  • Phytosome: 500 mg, 2x daily

Benefits:

  • Quercetin is found in fruits and vegetables and has a wide range of benefits, including decreasing viral growth
  • Enhances the immune system
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action:

Promote viral eradication or inactivation[9]-[13]:

  • Inhibition of viral replication

Favorably modulate viral-induced pathological cellular processes:

  • Modulation of NLRP3 inflammasome activation[5],[14],[15]

Mechanistically promote resolution of collateral damage and restoration of function:

  • Modulation of mast cell stabilization (anti-fibrotic)
Quercetin in the Fullscript catalog

Zinc

Dosing: 30-60 mg orally daily, in divided doses

  • Zinc acetate, citrate, picolinate, or glycinate orally
  • Zinc gluconate as lozenge

Benefits:

  • A large body of research shows that zinc has strong anti-viral properties against many viruses
  • Enhances the immune system
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action[120]-[127]:

Favorably modulate innate and adaptive immune system

Favorably modulate viral-induced pathological cellular processes, attachment, and replication

Zinc in the Fullscript catalog

N-Acetylcysteine (NAC)

Dosing: 600-900 mg, 2x daily

Benefits:

  • N-acetylcysteine promotes the production of glutathione, a potent antioxidant that supports immune function. It also reduces the severity of the flu
  • Enhances the immune system
  • Reduces symptoms

Viral-Specific Mechanism(s) of action[36]:

Favorably modulate cellular defense and repair mechanisms

NAC in the Fullscript catalog

Vitamin D

Dosing: 5,000 IU orally, daily

Benefits:

  • Vitamin D enhances immune system function, reduces viral growth, and can reduce upper respiratory infections
  • Enhances the immune System
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action[55]-[78]:

Favorably modulate cellular defense and repair mechanisms:

  • Activation of macrophages
  • Stimulation of anti-microbial peptides
  • Modulation of defensins
  • Modulation of TH17 cells

Favorably modulate viral-induced pathological cellular processes:

  • Reduction in cytokine expression
  • Modulation of TGF beta
Vitamin D in the Fullscript catalog

Vitamin A

Dosing: 10,000-25,000 IU, daily

Benefits:

  • Vitamin A is anti-inflammatory, enhances immune function, and supports the lining of the respiratory tract
  • Enhances the immune system
  • Reduces symptoms

Viral-Specific Mechanism(s) of action[95],[96]:

Favorably modulate cellular defense and repair mechanisms:

  • Modulation of T helper cells
  • Modulation of sIgA

Favorably modulate viral-induced pathological cellular processes:

  • Modulation of cytokine production
Vitamin A in the Fullscript catalog

Vitamin C

Dosing: 1-3 g orally, daily

Benefits:

  • Vitamin C contributes to immune defense by supporting various cellular functions of the immune system
  • Enhances the immune system
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action[120]:

Favorably modulate cellular defense and repair mechanisms

Favorably modulate viral-induced pathological cellular processes

Vitamin C in the Fullscript catalog

Melatonin

Dosing: 5-20 mg, taken at bedtime

Benefits:

  • In addition to promoting restful sleep, melatonin has been shown to reduce inflammation
  • Enhances the immune system
  • Decrease viral growth

Viral-Specific Mechanism(s) of action:

Favorably modulate viral-induced pathological cellular processes

  • Modulation of NLRP3 inflammasome activation[83],[84]
Melatonin in the Fullscript catalog

Elderberry (Sambucus nigra)

Dosing: 500 mg orally, daily

Benefits:

  • Elderberry is packed with vitamin C, dietary fiber, and antioxidants. It has been used extensively in the prevention of influenza
  • Enhances the immune system
  • Decrease viral growth

Viral-Specific Mechanism(s) of action[103],[107],[108],[109],[110],[111],[112]:

Favorably modulate cellular defense and repair mechanisms

Favorably modulate viral-induced pathological cellular processes

Elderberry in the Fullscript catalog

Palmitoylethanolamide (PEA)

Dosing: 300 mg orally, 2x daily (prevention); 600-900 mg, 3x daily for 2 weeks (treatment)

Benefits:

  • PEA is a naturally occurring anti-inflammatory agent that has been shown to improve outcomes in acute respiratory disease and influenza
  • Enhances the immune system
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action[115]:

Favorably modulate cellular defense and repair mechanisms

Favorably modulate viral-induced pathological cellular processes

PEA in the Fullscript catalog

Epigallocatechin gallate (EGCG)

Dosing: 4 cups daily (green tea) 225 mg orally, daily (EGCG)

Benefits:

  • In addition to reducing inflammation, green tea enhances the immune system and targets one of the processes involved in viral replication
  • Enhances the immune system
  • Decrease viral growth
  • Reduces symptoms

Viral-Specific Mechanism(s) of action:

Favorably modulate viral-induced pathological cellular processes:

  • Modulation of NLRP3 inflammasome activation[5],[28],[29]
Green tea in the Fullscript catalog

Resveratrol

Dosing: 100-150 mg orally, 2x daily

Benefits:

  • Resveratrol, a natural compound found in red grapes, has many beneficial health effects and has been shown in the lab to attack viral-specific agents
  • Enhances the immune system
  • Decrease viral growth

Viral-Specific Mechanism(s) of action:

Favorably modulate viral-induced pathological cellular processes

  • Modulation of NLRP3 inflammasome activation[5]
Resveratrol in the Fullscript catalog

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