Brand Protocol

Intestinal Permeability

This protocol was developed for practitioners using Fullscript in Canada and the templates cannot be applied to accounts operating outside of Canada.


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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Intestinal Permeability

Total Protocol Duration: 12 weeks

Pro DysbioX

1-2 softgels, 3 times daily, week 1 to 4.

Description: A broad spectrum anti-microbial and anti-spasmodic to relieve intestinal pain with gas commonly seen with IBS.

Note: Patient may experience mild mint taste after ingestion which can be reduced by storing the formula in the fridge.

Pro GI Repair

1 scoop, twice daily before food, week 1 to 12. Mix in water and take on an empty stomach.

Description: Anti-inflammatory that promotes the healing of GI lining. B. LongumBB536 studied to reduce dysbiosis and reduce pain scores in IBS.

Note: If there is no relief after 6 weeks, assess for SIBO and dysbiosis as they are often an underlying cause of IBS. See dysbiosis protocol.

Pro De-Stress

1 capsule, 2-3 times per day with food, week 1 to 12. Once anxiety and excess SNS are stable, can use as needed on an empty stomach. 

Description: Fast acting anti-anxiety support. Holy basil provides adaptogenic and blood sugar balancing effects.

Note: Consider interventions that reduce an exacerbated stress response and anxiety, such as meditation, diaphragmatic breathing, yoga, CBT, etc.


1 capsule, three times per day with food, week 5 to 12.

Description: Studied combination of probiotics that promote butyrate production, bifidobacterium growth and reduce intestinal pH.

Pro Tryfonia

1 capsule, 2 to 3 times daily on an empty stomach, week 1 to 12.

Description: Prokine-5-HTP binds to serotonin receptors in the gut, which improves motility.

Note: Not to be used with SSRIs


The following may be considered according to requirements for additional support:

  • Prokinetics are helpful for IBS-C, including melatonin, ginger (found in Pro GI Repair), and 5-HTP.
  • Ensure 5-6 hours between meals to encourage Migrating Motor Complex (MMC) activity.
  • In patients with insomnia as a co-morbidity, melatonin has been shown to module gastric motility and provide benefit in this condition.
  • Consider avoiding antigenic foods, which contribute to the reduction of IgA and promote chronic intestinal inflammation.



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