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Welcome to the final issue of The Script’s cardiometabolic series. This issue explores trending topics related to weight management and metabolic health. Continue reading to discover the latest innovations in this health space.
Dive in, and learn more about:
- Protocols for metabolic health and weight management
- Quality concerns in weight loss dietary supplements
- The latest integrative insights and research
- Dietary ingredients for weight management
- Emerging AI technologies
- Supplement learning opportunities
Protocols for metabolic health and weight management
Key ingredients for managing GLP-1 side effects
This protocol is formulated to support the use of GLP-1 agonists by alleviating potential side effects and supporting healthy weight management. Key ingredients include ginger to reduce nausea, probiotics for gastrointestinal comfort, protein to preserve muscle mass during weight loss, creatine for muscle support, and a multivitamin to ensure adequate micronutrient intake.
Foundational ingredients for weight management
This protocol focuses on supporting weight management. It incorporates foundational evidence-based ingredients such as whey protein, omega-3 fatty acids, probiotics, epigallocatechin gallate (EGCG), fiber, and conjugated linoleic acid (CLA).
Specialty ingredients for weight management
OvationLab and Fullscript have partnered to create a protocol featuring evidence-based supplement ingredients for supporting weight management. This protocol, similar to our Vascular Health and Post-viral Recovery protocols, is one of the many ways in which OvationLab and Fullscript are helping practitioners to prescribe evidence-based, high-quality whole-person care.
Quality corner
Quality concerns in weight loss dietary supplements
A recently published study investigated dietary supplements marketed for weight loss, specifically those offering military discounts, to determine their labeling accuracy and the presence of substances prohibited by the Department of Defense.
Of the 30 weight loss supplements purchased and analyzed, 25 (83%) were found to have inaccuracies on their labels; 24 (80%) had ingredients listed on the label that weren’t detected in the product; seven (23%) contained hidden substances not listed on the labels, ten (33%) contained one or more ingredients that are prohibited by the Department of Defense; and nine (30%) contained stimulants banned in sports.
Clinical takeaway: This study highlights the critical need for third-party testing to address widespread issues of mislabeling and the inclusion of potentially harmful and banned substances in dietary supplements marketed for weight loss.
Integrative insights
Glycemic control and early time-restricted eating
A systematic review and meta-analysis, including 20 studies, investigated the effects of time-restricted eating (TRE) on glycemic parameters. Although TRE didn’t significantly alter fasting glucose levels, it did reduce HbA1C, fasting insulin, and insulin resistance (HOMA-IR). The improvements in these parameters are particularly significant when food intake is consumed early rather than later in the day.
Clinical takeaway: Consider early TRE as a strategic intervention to effectively enhance glycemic control in patients with overweight or obesity.
Overnutrition and iron deficiency in youth
A systematic review, including 83 observational studies, examined the relationship between micronutrient status—specifically iron, zinc, and vitamin A—and weight status in young people (under 25 years of age). The findings show that overnutrition, including overweight and obesity, significantly increases the likelihood of iron deficiency. The study didn’t find similar associations with zinc and vitamin A deficiencies.
Clinical takeaway: Consider screening youth with overweight or obesity for iron deficiency and provide them with nutritional guidance to enhance their iron intake.
Apple cider vinegar and weight management in youth
A randomized, double-blind, placebo-controlled trial assessed the impact of apple cider vinegar (ACV) on weight and metabolic health in individuals with overweight or obesity (mean age 17). Participants received varying doses of ACV (5 mL, 10 mL, or 15 mL) or placebo over 12 weeks. By week 12, those receiving higher doses experienced more pronounced reductions in body weight, body mass index (BMI), waist and hip circumferences, and body fat ratio. Notable changes in body composition were primarily observed after eight weeks, regardless of the dose. Significant decreases in serum glucose, triglyceride, and cholesterol levels were particularly evident with the 15 mL dosage over the 12 weeks.
Clinical takeaway: Consider including apple cider vinegar as part of a holistic treatment plan to support metabolic health and weight management in young patients with overweight or obesity.
Supplement ingredient for weight management
Amarasate®
Amarasate® is a patented dietary extract from bitter hops. In a small study involving men who fasted for 24 hours, those who consumed Amarasate® experienced a significant reduction in hunger compared to those who took a placebo.
Emerging technology
Artificial intelligence in healthcare
The use of artificial intelligence (AI) in healthcare is revolutionizing the medical field by enhancing diagnostic accuracy, improving patient care, and optimizing data management. AI technologies like machine learning algorithms can analyze vast amounts of medical data quickly, aiding in early disease detection and personalized treatment plans. However, the integration of AI also presents challenges, including ethical issues, data privacy concerns, and regulatory hurdles.
Learning opportunities
Supplement Certification – Module 1: Introduction to Supplements
With 74% of Americans reporting taking dietary supplements and over 180,000 products on the market, it’s essential for practitioners to make informed clinical decisions about supplement use.
Fullscript is excited to announce the launch of a new supplement certification course in partnership with the American Association of Anti-Aging Medicine (A4M)! This course will equip you with the knowledge and tools to confidently navigate this complex landscape. Learn how to evaluate supplements for safety, efficacy, and quality and gain practical insights into incorporating evidence-based recommendations into your practice.
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