Autoimmunity is a disorder of the acquired immune system. This system is responsible for identifying, targeting, and eliminating pathogens such as bacteria, parasites and viruses. In individuals with autoimmune conditions, the immune reaction is irregular and targets the body’s own tissues. Examples of autoimmune diseases include Grave’s disease, multiple sclerosis (MS), psoriasis, rheumatoid arthritis, and type 1 diabetes. (12)
The autoimmune protocol diet has been proposed as a method to address autoimmune conditions. Let’s examine the connection between diet and autoimmune disease, as well as the autoimmune protocol diet, how it works, and its health benefits.
Diet and autoimmune disease: what’s the connection?
Diet is connected to autoimmunity and autoimmune disease through its effects on the gut and gastrointestinal microbiota, the collection of microbes residing in the gut. Dietary changes have been shown to affect the function and composition of these microbes, which is associated with immune system changes. (17)
Preclinical research suggests that modifying populations of certain gut bacteria may result in a disordered immune response and inflammation in the central nervous system. (7) Certain dietary factors may impair the integrity of the gastrointestinal (GI) barrier, resulting in increased intestinal permeability, commonly referred to as leaky gut. (16) When this occurs, harmful substances may cross the GI barrier from inside the gut to the bloodstream and lymphatic system to be circulated throughout the body, (11) triggering the immune system to respond to these substances. (10) Leaky gut has been associated with autoimmune conditions such as celiac disease, (14) rheumatoid arthritis, (13) and type 1 diabetes. (2)
A healthy diet can also positively influence the microbiota and, as a result, reduce inflammation and autoimmunity. Certain beneficial bacteria and the metabolites they produce may have a protective effect against inflammation and autoimmune conditions such as MS. For example, various bacteria in the gut produce short-chain fatty acids (SCFAs), which have an anti-inflammatory effect in the gut. (7)
Additionally, certain elimination diet interventions have been suggested as autoimmune disease diets, such as a gluten-free diet, which is a treatment for and may be protective against celiac disease, (6) as well as the autoimmune protocol diet, examined in detail below.
What is the autoimmune protocol diet?
The autoimmune protocol diet (AIP) is a modification of the Paleolithic (Paleo) diet, (1)(4)(9) which was founded on the concept that food produced through modern farming and industrial production is not aligned with the evolution of the human body. The Paleo diet encourages the consumption of uncultivated plants, such as vegetables, fruit, roots, and nuts, as well as wild-sourced animal foods, such as fish, lean meat, and eggs. (8)
AIP incorporates these principles into a three-phase elimination protocol consisting of elimination, maintenance, and reintroduction phases. The goal of the protocol is to eliminate dietary additives, emulsifiers, Western dietary patterns, and specific foods to identify potential triggers of intestinal inflammation, dysbiosis (microbial imbalance) in the gastrointestinal tract, and symptoms of food intolerance. (1)(4)(9)
These dietary components are eliminated because they may disrupt the gastrointestinal microbiome and the intestinal barrier that protects us against harmful substances crossing the intestinal wall. Dysbiosis and intestinal barrier disruption are associated with immune dysfunction and the development of autoimmunity. (1)
Autoimmune protocol diet food list
The AIP emphasizes the intake of fresh, nutrient-dense, unprocessed foods, including:
- Bone broth
- Fermented foods and probiotics (4)(9)
- Foods high in mono and polyunsaturated fatty acids (e.g., avocados, seafood)
- Non-processed meats
- Organ meats (e.g., kidney, liver, sweetbreads)
- Poultry (e.g., chicken, turkey)
- Tubers (e.g., Jerusalem artichoke, parsnips, sweet potato)
- Wild game meats (e.g., bison, rabbit, venison) (1)
The autoimmune protocol diet plan
During the first phase of the AIP, elimination, an individual should restrict the following dietary components and substances:
- All grains
- Food additives (e.g., colors, flavors, preservatives)
- Industrial seed oils (e.g., canola, safflower, sunflower)
- Nightshades (e.g., eggplant, peppers, tomato, potatoes)
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Nuts and seeds
- Refined/processed sugars (4)(9)
The second phase, maintenance, involves maintaining the elimination of the above factors. The duration of the maintenance phase varies depending on the individual, and should be followed until well-being and symptoms are measurably improved. (4)(9) Consult with your integrative practitioner for individual dietary advice.
Phase three, reintroduction, involves the gradual reintroduction of food and food groups. Introducing foods in stages allows the individual to identify specific dietary components that may be associated with symptoms. (4)(9)
How does the AIP diet work?
Elimination diets, including the AIP, may exert benefits as a result of several factors, which include:
- Rebalancing gut microbiota
- Reducing the number of proinflammatory bacteria
- Regulating immune response
- Promoting healing of gastrointestinal mucosa
- Providing beneficial nutrients (5)
Health benefits: What do the studies say?
AIP for inflammatory bowel disease
Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are inflammatory conditions characterized by an irregular immune response in the gastrointestinal tract. (3) Multiple clinical trials have examined the effects of the AIP diet with a six-week elimination phase and a five-week maintenance phase in individuals with IBD.
One study that followed this structure found that the majority of participants (73%) achieved and maintained remission of their condition during the first two phases. (5) A second trial of the AIP diet in individuals with IBD suggested that quality of life may be improved in as little as three weeks of following the diet. Beginning at three weeks, improvements were seen in stress, bowel movement frequency, and the ability to perform leisure activities. (4) In a third study following this format in adults with active IBD, the dietary intervention was associated with improved symptoms and tissue inflammation viewed by endoscopy. (9)
While these studies suggest that AIP may help improve the symptoms and inflammatory disease activity seen in IBD, randomized controlled trials are required to further explore the long-term effects and potential applications of the dietary protocol. (4)(9)
AIP for Hashimoto’s thyroiditis
One pilot study assessed the effect of the AIP as part of a broader lifestyle intervention program in adult women with Hashimoto’s thyroiditis, an autoimmune condition resulting in reduced activity of the thyroid gland (hypothyroidism). (15) The study results included a decrease in white blood cell counts and a decrease in high-sensitivity C-reactive protein (hs-CRP), which suggests that the AIP may modulate the immune system and reduce inflammation. Overall, the diet and lifestyle program was found to improve symptoms and health-related quality of life in women with Hashimoto’s. (1)
The bottom line
Is the AIP diet the best diet for autoimmune disease? The autoimmune protocol diet is an intervention suggested to address autoimmune conditions by minimizing dietary factors associated with inflammation and autoimmunity. Benefits of this intervention have been seen in individuals with IBD and Hashimoto’s thyroiditis. Longer, well-designed trials are needed to further establish the effects of the AIP in individuals with autoimmune conditions. (1)(5) As always, it’s recommended to work with an integrative practitioner that can help you to implement dietary modifications safely and effectively for your individual needs.
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- Abbott, R. D., Sadowski, A., & Alt, A. G. (2019). Efficacy of the autoimmune protocol diet as part of a multi-disciplinary, supported lifestyle intervention for Hashimoto’s thyroiditis. Cureus, 11(4), e4556.
- Arrieta, M. C., Bistritz, L., & Meddings, J. B. (2006). Alterations in intestinal permeability. Gut, 55(10), 1512–1520.
- Centers for Disease Control and Prevention. (2019, December 29). Inflammatory bowel disease (IBD). Retrieved from https://www.cdc.gov/ibd/index.htm
- Chandrasekaran, A., Groven, S., Lewis, J. D., Levy, S. S., Diamant, C., Singh, E., & Konijeti, G. G. (2019). An autoimmune protocol diet improves patient-reported quality of life in inflammatory bowel disease. Crohn’s & Colitis 360, 1(3), otz019.
- Chandrasekaran, A., Molparia, B., Akhtar, E., Wang, X., Lewis, J. D., Chang, J. T., … Konijeti, G. G. (2019). The autoimmune protocol diet modifies intestinal RNA expression in inflammatory bowel disease. Crohn’s & Colitis 360, 1(3), otz016.
- Cosnes, J., Cellier, C., Viola, S., Colombel, J., Michaud, L., Sarles, J., … Mouterde, O. (2008). Incidence of autoimmune diseases in celiac disease: Protective effect of the gluten-free diet. Clinical Gastroenterology and Hepatology, 6(7), 753–758.
- Haase, S., Haghikia, A., Wilck, N., Müller, D. N., & Linker, R. A. (2018). Impacts of microbiome metabolites on immune regulation and autoimmunity. Immunology, 154(2), 230–238.
- Klonoff, D. C. (2009). The beneficial effects of a paleolithic diet on type 2 diabetes and other risk factors for cardiovascular disease. Journal of Diabetes Science and Technology, 3(6), 1229–1232.
- Konijeti, G. G., Kim, N., Lewis, J. D., Groven, S., Chandrasekaran, A., Grandhe, S., … Torkamani, A. (2017). Efficacy of the autoimmune protocol diet for inflammatory bowel disease. Inflammatory Bowel Diseases, 23(11), 2054–2060.
- Morris, G., Berk, M., Carvalho, A., Caso, J., Sanz, Y., & Maes, M. (2016). The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimmune processes with an emphasis on inflammatory bowel disease, type 1 diabetes, and chronic fatigue syndrome. Current Pharmaceutical Design, 22(40), 6058–6075.
- Mu, Q., Kirby, J., Reilly, C. M., & Luo, X. M. (2017). Leaky gut as a danger signal for autoimmune diseases. Frontiers in Immunology, 8.
- National Institutes of Arthritis and Musculoskeletal and Skin Diseases. (2020, February 26). Autoimmune diseases. Retrieved from https://www.niams.nih.gov/health-topics/autoimmune-diseases/advanced
- Odenwald, M. A., & Turner, J. R. (2016). The intestinal epithelial barrier: A therapeutic target? Nature Reviews Gastroenterology & Hepatology, 14(1), 9–21.
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- Pyzik, A., Grywalska, E., Matyjaszek-Matuszek, B., & Roliński, J. (2015). Immune disorders in Hashimoto’s thyroiditis: What do we know so far? Journal of Immunology Research, 2015, 1–8.
- Sander, G. R., Cummins, A. G., & Powell, B. C. (2005). Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Letters, 579(21), 4851–4855.
- Vieira, S. M., Pagovich, O. E., & Kriegel, M. A. (2014). Diet, microbiota and autoimmune diseases. Lupus, 23(6), 518–526.