The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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The PureResponseTM Immune Protocol – Innate Immunity & Th1 Support Protocol (Left Loop)

Developed with Samuel F. Yanuck, D.C., FACFN, FIAMA+

Protocol Objective:

This protocol is intended for patients in need of support for both innate immunity and Th1 response. These patients are often characterized by altered immune surveillance and intestinal microbial balance. The products in this protocol are designed to promote cytokine balance and cell-mediated immunity (including natural killer cell and macrophage activity), as well as healthy Th1 cell status.‡


Innate Immune Support

1 capsule, once to twice per day, with or between meals, minimum 3 months

Download the US product monograph

Th1 Support

2 capsules, once to twice per day, with or between meals, minimum 3 months

Download the US product monograph

Balanced Immune

1 capsule, once to twice per day, with or between meals, minimum 3 months

Download the US product monograph

Additional Support Products:

  • Black Currant Seed Oil
  • NAC 600 mg
  • Liposomal Glutathione

Acute/Intensive Support for Self-tissue Response:

  • Consider increasing the dose of Innate Immune Support, Th1 Support, and Balanced Immune and/or introducing one or more of the following:
    • Th2 Modulator
    • Liposomal Glutathione
    • Vitamin D3



When applying the PureResponseTM Immune Protocols, supplementation with Th1 Support will not be appropriate for a small subset of patients. This small subset is typically identified by a recent, vigorous onset of self-tissue response, most often associated with the need for joint support or joint comfort. Labs may indicate a need to modulate monocyte response (percentage). For these patients, supplementation with Balanced Immune may be indicated.




The initial application of the PureResponseTM Immune Protocols is intended to be three to six months. After this period, product dosages may be lowered or discontinued if appropriate, based on patient status, Cogence Brief Immunological Assessment results, lab test results, and the clinician’s impression of the ongoing need for support.