Supporting the body’s detoxification pathways is crucial for maintaining hormone health. Hormonal imbalances often arise not just from hormone levels themselves but also from how the body metabolizes and eliminates these hormones through stool and urine. A comprehensive approach to hormone health should, therefore, include personalized nutritional and herbal support for these detoxification processes.

For that reason, this protocol is divided into three parts: foundational functional systems (parts I and II), which are key for all women, and individual symptomatic support (part III), which is used on a patient-by-patient basis. All these are combined with exercise, lifestyle, emotional, and other whole-health support.

Part I – Foundational support

pH QuintessencePRO (Symphony Natural Health)

Dosing: Take 1 capsule in the morning and 2 capsules in the evening

pH QuintessencePRO is a 40:1 concentrated alfalfa (Medicago sativa) preparation that is rich in vitamins, minerals, essential amino acids, fatty acids, antioxidants, carotenoids, and chlorophyll. It’s designed to support detoxification and the gut microbiome and helps maintain the body’s natural alkalinity and pH levels.*

 

Part II – Foundational nutrition and hydration support

Personalized nutrition support

In addition to foundational nutrition products listed here, there may be other nutrients (e.g., iron, biotin) required for an individual based on personal characteristics, such as their gene variants, dietary pattern, physical activity, environment, and toxin load.

 

Nutrition support

MediClear Plus (Thorne)

Dosing: Mix 1 serving (2 scoops) with at least 8 oz of cold water, juice, rice milk, or nut milk

MediClear Plus is a low-allergenic, rice-and-pea-protein-based supplement that’s formulated to support liver and colon detoxification.*

 OR

UltraClear RENEW (Metagenics)

Dosing: Blend, shake, or briskly stir about 2 level scoops (36 g) of UltraClear RENEW into 8 fl oz of chilled water or juice twice daily. For highly sensitive individuals, consider reducing consumption to ½–1 scoop with 4–5 oz of chilled water or juice twice daily during the first 3–4 days before starting a full daily dose.

This formula delivers advanced, specialized nutritional support for phase I, II, and III detoxification, with enhanced support for the body’s natural alkalinization and heavy metal metabolism processes.*

 

Hydration support

Original Himalayan Crystal Salt: Stones (Symphony Natural Health)

Dosing: Add 1 tsp of Himalayan crystal salt to 8–12 oz of purified water. Drink each morning on an empty stomach and wait 30 minutes before eating.

The solution contains 84 ionic trace minerals inside the salt crystal matrix structure in a form that can be easily absorbed and metabolized by the body. It supports hydration, electrolytes, cellular communication, and pH balance. Sole Therapy may help support overall cellular health and mineral status. It’s free of chemicals, pollution, and microplastics.

 

Part III – Additional functional and individual symptomatic support

Healthy estrogen metabolism support

EstroFactors (Metagenics)

Dosing: 2 capsules 1–2 times daily

EstroFactors is a unique formula featuring phytonutrients that provide targeted support for estrogen metabolism.*

 

Phase I and II support

AdvaClear® (Metagenics)

Dosing: 2 capsules once daily

AdvaClear® provides methylated B12 and folate along with bifunctional nutritional support designed to help enhance the activities of several liver detoxification enzymes and support phase I and phase II detoxification pathways.*

GlutaClear® (Metagenics)

Dosing: 2 tablets twice daily with food

GlutaClear® features a blend of key ingredients designed to help increase the body’s production of glutathione, a primary antioxidant throughout the entire body.*

NAC (Integrative Therapeutics)

Dosing: 1 capsule 1–2 times daily

NAC supports tissue levels of glutathione, a key component of the antioxidant defense system.*

Liposomal Glutathione, Lemon Mint Flavor (Quicksilver Scientific)

Dosing: 2 pumps by mouth twice daily. Hold in mouth for 30 seconds before swallowing. Repeat to the desired dosage. Take on an empty stomach at least ten minutes before meals. 

Glutathione may support healthy aging, immune health, and energy levels.*

 

Gut support

FiberMend (Thorne)

Dosing: Mix 1 scoop with at least 8–10 oz of water, juice, or preferred beverage daily. Start low in dose and ramp up over 7–10 days to minimize bloating.

FiberMend combines Sunfiber®, a partially hydrolyzed guar gum fiber, with rice bran, larch arabinogalactan, apple pectin, and green tea phytosome in a water-soluble blend.

Calcium-D-Glucarate (Pure Encapsulations)

Dosing: 1–6 capsules per day, in divided doses, with meals

Calcium-D-Glucarate is a patented form of glucaric acid, a nutrient with the potential to support healthy detoxification and cellular function.*

 

Methylation Support

MethylCare™ (Metagenics)

Dosing: 2 capsules once daily

MethylCare™ is a comprehensive formula that features calcium L-5-methyltetrahydrofolate, nature-identical folate—along with N-acetyl-L-cysteine, vitamins B6 and methylated B12, and betaine HCl.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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