Understanding the physiological mechanisms of metabolic health and weight management is essential for developing new and targeted approaches for clinical management. Growing evidence suggests that gut microbiota may contribute to many aspects of metabolic health. 

Specific gut-focused solutions are being identified for managing metabolic health and body weight. For example, bacterial strains such as Clostridium butyricum and Faecalibacterium prausnitzii possess genes that stimulate butyrate production. Additionally, Akkermansia muciniphila, a keystone bacterial strain, secretes a P9 protein that stimulates GLP-1 production.

Pendulum supplement plan


GLP-1 Probiotic Pro (exclusive to Fullscript)

Dose: 1 capsule, once daily with food

Description: GLP-1 Probiotic Pro is an innovative multi-strain probiotic (500 million AFU/serving) formulated to help support healthy blood sugar and satiety levels.* GLP-1 Probiotic Pro contains live Akkermansia muciniphila, Clostridium butyricum, and Bifidobacterium infantis, as well as chicory inulin prebiotic fiber.

Polyphenol Booster  

Dose: 2 capsules, once per day 

Description: Polyphenol Booster is an optional polyphenolic blend to help support Akkermansia muciniphila levels.* It contains pomegranate extract (375 mg), grape seed extract (275 mg), and green tea extract (225 mg). 


Other supplements

Omega-3 fatty acids  

Dose: variable 

Description: Omega-3 fatty acids are an optional add-on to boost Akkermansia muciniphila levels.


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.