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Neurological Health – Headaches

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Neurological Health – Headaches

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through C-quality evidence.

Systematic review or meta-analysis of human trials
RDBPC human trials
2+ studies and/or 1 study with 50 + subjects
RDBPC human trials
1 study

Butterbur (Petasites hybridus)

100-150 mg, total per day, minimum 12 weeks1,2

  • Petasites hybridus is well-tolerated and is recommended as an alternative for prophylactic treatment in migraine patients1,2,3,4
  • A 50% to 68% decrease in frequency of migraine attacks was observed1,2,3,4
Petasites hybridus in the Fullscript catalog

Feverfew (Tanacetum parthenium)

50-100 mg, total per day, minimum 8 weeks6

  • Feverfew has been shown to be beneficial in the prevention of migraines5,7
  • Migraine frequency, severity, and degree of vomiting was shown to be reduced8,9,10
  • Although shown to be safe, Tanacetum parthenium possesses cyclooxygenase-2 (COX-2) inhibition activity; long-term use could be of concern5,7,8,9,10
Feverfew (Tanacetum parthenium) in the Fullscript catalog


600 mg, total per day of magnesium citrate, minimum 12 weeks11,14,15

  • A reduction in the intensity and number of migraine attacks was observed when a high level of magnesium is administered (600 mg qd)11,14
  • An increase in cortical blood flow in the insular regions, inferolateral frontal and inferolateral temporal was observed after magnesium treatment15
  • Intravenous magnesium has been shown to decrease acute migraine attacks within 15 minutes to 24 hours after the initial administration12,13
  • High dose of magnesium is well-tolerated, however, adverse events including diarrhea and gastric irritation have been noted11,14
Magnesium in the Fullscript catalog


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials

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