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The gut-brain axis is a complex, bidirectional communication system between the gastrointestinal tract and the central nervous system. The gut microbiota influences the gut-brain axis. Therefore, changes in the gut microbiota due to factors such as diet and stress may lead to gastrointestinal and psychiatric concerns.

The following is an evidence-based eight-week protocol for supporting the gut-brain axis, the gut microbiota, and mental health.

Product descriptions


ZenbiomeTM DUAL contains the novel psychobiotic Bifidobacterium longum 1714™ and the internationally recognized probiotic Bifidobacterium longum 35624™. B. longum 1714™ may help support the cortisol/stress response and promote relaxation and emotional well-being. B. longum 35624™ may help support digestive health and healthy inflammatory levels.* 

Some patients may experience some gut changes or discomfort during the first four weeks. This is temporary and an indication that the probiotic cultures are beginning to take effect.



MegaMarine™ is a comprehensive, full-spectrum fish oil formulated to support a healthy gut microbiome. It contains a balanced ratio of EPA, DHA, and the “forgotten” DPA to support healthy immune and gut-barrier function.* 


Mega IgG2000™

Serum-derived bovine immunoglobulins, found in MegaIgG2000™, may help support a balanced immune system and a healthy gut barrier.*

If patients experience diarrhea, increase by two capsules per day to a dose of 5 g, as tolerated.



MegaSporeBiotic™ is a 100% spore-based probiotic that supports the gut microbiome by promoting microbial diversity and maintaining health-promoting, commensal gut microbes.* 



FODMATE is a FODMAP-specific enzymatic blend to support the digestion of fermentable oligosaccharides, disaccharides, and/or monosaccharides.*

Recommend in one- to three-month increments as long-term use will result in decreased microbial diversity.

Dosing schedule

Week 1 Week 2 Weeks 3–4 Weeks 5–8
Zenbiome™ DUAL 2 capsules per day with a meal 
MegaMarine™  2 softgels per day with a meal
Mega IgG2000™  2 capsules twice per day with a meal
MegaSporeBIotic™  1 capsule every other day 1 capsule per day 2 capsules per day 
FODMATE™  2 capsules, 2–3 times per day, 15–30 minutes before meals 


*These statements have not been evaluated by the Food and Drug Administration. This protocol is not intended to diagnose, treat, cure, or prevent any disease. The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help healthcare practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.