This protocol was developed for practitioners using Fullscript in Canada and the templates cannot be applied to accounts operating outside of Canada

Disclaimer

This protocol is produced by TallGrass Natural Health. TallGrass Natural Health is the exclusive Canadian distributor of MegaFood, Host Defense, Renew Life, and the manufacturer of Botanica.

MegaFood

Vitamin D3

1 tablet daily

1000 IU of FoodState Vitamin D3 is delivered with organic whole foods, including brown rice, parsley leaf, broccoli, carrot,  and beet root that provide synergistic cofactors for improved assimilation and activation of the vitamin.

Vitamin D has been shown to be an important contributor to cerebral activity in both the embryonic and adult brain. It supports the connectivity of neural circuits responsible for locomotor, emotional, and reward-dependent behavior. (5) Furthermore, deficiency may lead to an increased risk of disease of the central nervous system, particularly schizophrenia and multiple sclerosis. (6)

Magnesium

1 tablet daily

Highly absorbable FoodState magnesium synergistically paired with organic whole food kale to nourish adrenal glands and support the nervous system.

Despite being one of the most abundant minerals in the human body, more than half of adults in the United States do not consume the estimated average requirement for magnesium, according to data from a 2009 NHANES study. (7) Magnesium plays a critical role in nerve transmission and neuromuscular conduction. It also functions in a protective role against excessive excitation that can lead to neuronal cell death (excitotoxicity) and has been implicated in multiple neurological disorders. ix Magnesium is increasingly being studied for its potential to prevent and treat neurological disease.

Possible add-ons:

Vegan B12

1 tablet daily

A synergistic blend of FoodState vitamins B6, folic acid, and vegan B12 in a convenient mini-tablet, made with whole foods,  nutritional yeast, and added nutrients, is easy to swallow and can be taken any time of the day, even on an empty stomach.

Vitamin B12 deficiency can lead to damage to the myelin sheath that surrounds and protects nerves. Even a mild deficiency can negatively impact the nervous system. This is of particular concern with many vegans as there is an elevated risk of reduced intake of  Vitamin B12 in their diet.

Renew Life

Click to view Renew Life protocols

Super Critical Omega

1 softgel daily

A potent, super-concentrated fish oil supplement with 790 mg of EPA and 140 mg of DHA per capsule, to help support nerve health. Enteric-coated capsules made from fish gelatin. Added lipase and 1000 IU Vitamin D.

Omega-3 fatty acids appear to play a role in the promotion of remyelination after toxic injury to CNS oligodendrocytes. (4) This might occur either via modulation of the immune system or via a direct effect on oligodendrocytes or neurons through EPA-derived lipid metabolites’. (5)

Possible add-ons:

IntestiNew

1 scoop daily

An easy-to-mix powder formulation made with soothing herbal ingredients that help to rebuild and repair the intestinal tract lining. Contains 5000mg of L-Glutamine and 200mg of N-Acetylglucosamine per serving, along with the ginger root, marshmallow root, and other soothing herbs for the gut.

L-glutamine is a major substrate used by enterocytes. ‘Glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions’. (11) Glutamine is also abundant in the central nervous system where it participates in a variety of metabolic pathways and acts as a precursor for glutamate, aspartate, and GABA. (12) Current research is investigating its potential to prevent neuropathy caused by chemotherapy.

Host Defense Mushrooms

Click to view Host Defense Mushrooms protocols

Lion’s Mane Capsules or Liquid Extract

2 capsules daily or 1 mL, 2 times daily

Supports cognitive function. Promotes mental clarity, focus, and memory. Provides cerebral and nervous system support.

Lion’s Mane shines in its ability to activate Nerve Growth Factor (NGF) to aid in repair and regeneration in the nervous system. (1)(2) NGF protects oligodendrocytes, which are myelin-producing cells that are so important for nerve signal conduction. These studies show great potential in using Lion’s Mane in cases of nerve trauma, whether due to injury or surgery.

Possible add-ons:

MycoBotanicals Stress Decompress

2 capsules daily

Combines mushrooms and herbs to reduce the sympathetic nervous system while gently energizing the body and mind.

Reishi supports adrenal function while calming the fight or flight response. It has potent neuroprotective activity and is believed to contribute to neuronal survival. (13)(14) Lion’s Mane shines in its ability to activate Nerve Growth Factor (NGF) to aid in repair and regeneration in the nervous system. (15)(16) NGF protects oligodendrocytes, which are myelin-producing cells that are so important for nerve signal conduction. Skullcap and Lemon Balm help calm an overactive mind and have been traditionally used to restore and tone the nervous system. And Ashwagandha, a calming adaptogen, has shown the potential to improve communication between nerve cells and may be an important candidate for the therapeutic treatment of neurodegenerative diseases. (17)

Botanica

Click to view Botanica protocols

Possible add-ons:

One of the two following:

Turmeric Liquid Capsules

1-3 capsules daily 

Convenient capsules with the concentration of a liquid botanical. Rather than isolating curcumin, we use the whole plant with its complete range of compounds to maximize absorption into our digestive tract so it can be used by your body’s cells. CO2  Supercritical extraction allows for a high concentration of lipid compounds such as curcuminoids and turmerones without the use of solvents. Helps modulate inflammatory pathways that affect the heart, joints, liver, and cellular health.

Turmeric is well recognized for its powerful anti-inflammatory activity in the body and this has also been seen in the brain and nervous system. Curcumin, its most researched active compound, has been suggested as adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. With its ability to decrease Beta-amyloid plaques, delayed degradation of neurons, act as a  metal-chelator, anti-inflammatory, and antioxidant as well as decrease microglia formation. (9)(10) Turmeric can have an important impact on neurological health.  

Turmeric Pain Relief Liquid Capsules

2-6 capsules daily

Convenient capsules with the concentration of a liquid botanical. Rather than isolating curcumin, we use the whole plant with its complete range of compounds to maximize absorption. And then combine with a unique blend of herbs to support pain management and inflammation reduction, including nerve pain and inflammation.

Turmeric is well recognized for its powerful anti-inflammatory activity in the body and this has also been seen in the brain and nervous system. The second herb in this blend is Wild Lettuce, a plant that has been used historically to support nerves and promote restful sleep. The principal compounds in Wild Lettuce have been studied for various properties relating to the central nervous system and pain centers in the brain. Jamaican Dogwood has also been a traditional remedy for easing nerve pain, migraine, insomnia, and nervous tension. And finally, Rosemary has a well-known calming effect on the nervous system.

Perfect Greens – Unflavoured

1 scoop daily

A clean, organic blend of chlorella, spirulina, barley, and wheat grasses plus leafy greens to help top up and ensure that you’re getting your greens. Supports a healthy immune system and helps to alkalize, detoxify, and energize.

Cereal grasses such as Barley grass, Oat grass, and Wheatgrass, are packed with essential vitamins and minerals. They are a rich source of chlorophyll, a potent antioxidant. Cereal grasses also offer unique digestive enzymes that are not found in such concentrations in most other foods. In particular, they contain Super Oxide Dismutase (SOD), a powerful antioxidant that is highly valued for its ability to slow the aging process, as well as the degenerative process of many chronic diseases. Gluten-free – but not third party tested for celiacs. 

Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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References
  1. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Mori K, Obara Y, Hirota M, Azumi Y,  Kinugasa S, Inatomi S, Nakahata N., Biol Pharm Bull. 2008 Sep;31(9):1727-32.
  2. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. Wong KH, Kanagasabapathy  G, Naidu M, David P, Sabaratnam V., Chin J Integr Med. 2016 Oct;22(10):759-67.
  3.  B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine,  and cobalamin, CA Calderon-Ospina, MO Nava-Mesa, CNS Neuroscience and Therapeutics, 2019 Sept; Vol26, Issue 1
  4. The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice, Siegert E, Paul F, Rothe M, Weylandt KH. BMC  Neurosci. 2017;18(1):19. Published 2017 Jan 24
  5. Vitamin D and the nervous system, Giulia Bivona, Caterina Maria Gambino, Giorgia Iacolino & Marcello Ciaccio (2019), Neurological  Research, 41:9, 827-835
  6. Vitamin D and the central nervous system. Wrzosek M, Łukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piątkiewicz P, Radziwoń-Zaleska M, Wojnar M, Nowicka G. Pharmacol Rep. 2013;65(2):271-8
  7. What We Eat in American NHANES 2005-2006, Usual Nutrient Intakes from Food And Water Compared to 1997 Dietary  Reference, A Moshfegh et al.
  8. The Role of Magnesium in Neurological Disorders. Kirkland AE, Sarlo GL, Holton KF. Nutrients. 2018;10(6):730. Published 2018 Jun 6
  9. An overview of curcumin in neurological disorders, Kulkarni SK, Dhir A. Indian J Pharm Sci. 2010;72(2):149-154 xi
  10. The effect of curcumin (turmeric) on Alzheimer’s disease: An overview, Mishra S, Palanivelu K. Ann Indian Acad Neurol.  2008;11(1):13-19
  11. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Kim MH, Kim H. Int J Mol Sci. 2017;18(5):1051.  Published 2017 May 12.
  12. Roles of glutamine in neurotransmission. Albrecht J, Sidoryk-Węgrzynowicz M, Zielińska M, Aschner M. Neuron Glia Biol. 2010  Nov;6(4):263-76
  13. Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Sun XZ, Liao  Y, Li W, Guo LM. Neural Regen Res. 2017;12(6):953-958
  14. Triterpenoids with neurotrophic activity from Ganoderma lucidum. Zhang XQ, Ip FC, Zhang DM, Chen LX, Zhang W, Li YL, Ip NY, Ye  WC. Nat Prod Res. 2011 Oct;25(17):1607-13
  15. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Mori K, Obara Y, Hirota M, Azumi  Y, Kinugasa S, Inatomi S, Nakahata N., Biol Pharm Bull. 2008 Sep;31(9):1727-32.
  16. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. Wong KH, Kanagasabapathy  G, Naidu M, David P, Sabaratnam V., Chin J Integr Med. 2016 Oct;22(10):759-67.
  17. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Kuboyama T, Tohda C, Komatsu K. Br J Pharmacol.  2005;144(7):961-971