Healthy Aging Protocol

Longevity Support

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Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through D-quality evidence.

Systematic review or meta-analysis of human trials
RDBPC human trials
2+ studies and/or 1 study with 50 + subjects
RDBPC human trials
1 study
Non-RDBPC human or In-vivo animal trials


Multivitamin formulation, minimum 8 weeks1

  • Multivitamin use was associated with longer telomere length in women aged 35 to 742
  • Multivitamins containing a combination of minerals and herbs were shown to decrease perceived mental stress in an elderly population several hours after intake4
  • Multivitamin intake in elderly women was associated with an increase in inhibitory neural processes, which translates into an improvement in neural efficiency during memory retrieval3
  • Multivitamins were shown to improve alertness and negative mood symptoms in men aged 50 to 69 years old1
Multivitamin in the Fullscript catalog

Omega-3 fatty acids

1.25-2.5 g of Omega-3 PUFA, total per day, minimum 8 weeks5,6,7

  • Omega-3 PUFA has been shown to increase telomerase levels and lengths5,6
  • Omega-3 PUFAs have shown to reduce IL-1β, TNF-α, and IL-6, factors that contribute to the effects of inflammaging7

For a more detailed review of Omega 3 fatty acids, refer to the Fullscript reference sheet:

Omega-3 fatty acids in the Fullscript catalog

New and upcoming research:

Astragalus membracanus

10-50 mg of TA-65, total per day, minimum 12 months8

  • Decline in the percentage of senescent cytotoxic T cells (CD8+ and CD28-) and natural killer cells were observed in seropositive patients9
  • TA-65 has been demonstrated a clinically significant effect in lengthening telomerase and decreasing the percentage of short telomerase8,9
Astragalus membracanus in the Fullscript catalog


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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Fullscript content philosophy

At Fullscript, we are committed to curating accurate, and reliable educational content for practitioners and patients alike. Our educational offerings cover a broad range of topics related to integrative medicine, such as supplement ingredients, diet, lifestyle, and health conditions.

Medically reviewed by expert practitioners and our internal Integrative Medical Advisory team, all Fullscript content adheres to the following guidelines:

  1. In order to provide unbiased and transparent education, information is based on a research review and obtained from trustworthy sources, such as peer-reviewed articles and government websites. All medical statements are linked to the original reference and all sources of information are disclosed within the article.
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