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Adrenal Support

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

As a result, the Fullscript Integrative Medical Advisory team advises using an evidence-informed approach to protocol development. To simplify this process for practitioners, we have assembled a sampling of evidence-based standardized protocols that practitioners can use as a foundation when developing individualized protocols.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through D-quality evidence. These are categorized as follows:

Class Qualifying studies Minimum requirements
A Systematic review or meta-analysis of human trials
B Human RDBPC ≥ 2 studies and/or 1 study with ≥ 50
C Human RDBPC or RCT 1 study < 50 subjects
D Human trials or In-vivo animal trials

RDBPC = Randomized Double-Blind Placebo Controlled
RCT = Randomized Controlled Trials

Please refer to the complete Rating Scale for further information.


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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Adrenal Support

Ashwagandha (Withania somnifera)

300mg, total per day, minimum 8 weeks1,2

  • Serum cortisol, body weight, and body mass index, Perceived Stress Scale and Food Cravings Questionnaire, Oxford Happiness Questionnaire and Three-Factor Eating Questionnaire were all improved1,2
  • Ashwagandha safely improved resistance to stress in individuals2

For a more detailed review of Withania somnifera, refer to the Fullscript reference sheet: https://fullscript.com/hcp/withania-somnifera-reference

Withania Somnifera in the Fullscript catalog.

Rhodiola (Rhodiola rosea)

576mg, total per day, minimum 28 days3

  • Rhodiola increases mental performance including the capacity to concentrate and decreased cortisol response to awakening stress3
  • Improvement in general fatigue including aspects like physical and mental fatigue, neuro-motoric tests and overall wellbeing was shown to be significantly improved4,5

For a more detailed review of Rhodiola rosea, refer to the Fullscript reference sheet: https://fullscript.com/hcp/rhodiola-rosea-reference

Rhodiola rosea in the Fullscript catalog.

Panax ginseng

960-2000mg, total per day, minimum 4 weeks7,8

  • Numerical rating scale (NRS) score, a self-assessment of fatigue severity, was improved7
  • Panax has shown to reduce circulating cortisol while increasing enzymatic and nonspecific antioxidant activity in response to physical stress8
  • Dosing of 2000 mg per day improved the visual analogue scale (VAS) results7
  • Reactive oxygen species (ROS) and malondialdehyde (MDA) levels were lowered and a dosing of 1000 mg increased GSH concentration and activity7
Panax Ginseng in the Fullscript catalog.