SAMe + CoFactors 200mg

Supports mood, liver, and methylation health through carefully-formulated nutrient support.* What It Does SAMe with Cofactors provides targeted nutritional support for balanced mood, healthy liver function, and optimal methylation activity.*

This comprehensive formula combines S-adenosyl-L-methionine (SAMe) with essential methyl donors and cofactors including vitamin B6, active folate, and methylcobalamin to help sustain neurotransmitter synthesis, cellular detoxification, and energy metabolism.*

How It Works SAMe (S-adenosyl-L-methionine) — Serves as a universal methyl donor that supports serotonin, dopamine, and norepinephrine metabolism while promoting liver detoxification and phospholipid synthesis.* [1,2] L-5-Methylfolate:

— Provides the biologically active form of folate, essential for the remethylation of homocysteine and production of neurotransmitters involved in mood regulation.* [3,4] Vitamin B12 (as methylcobalamin)

— Works with folate and SAMe to maintain methylation balance, support nerve integrity, and aid in red blood cell formation.* [4,5] Vitamin B6 (as pyridoxal-5′-phosphate)

— Functions as a coenzyme in amino acid metabolism and assists in the synthesis of serotonin, GABA, and dopamine.* [5] Who It’s For Ideal for individuals seeking support for mood balance, cognitive clarity, and liver function, or those with increased methylation demands due to stress, genetic polymorphisms, or other situations.*

Special Features Features the active, bioavailable forms of B-vitamins including methylcobalamin, L-5-MTHF, and P-5-P for immediate utilization, with 400 mg of SAMe to optimize methylation efficiency. Free of gluten, soy, and manufactured under strict quality standards for purity and strength.*

References 1. Baden KER, et al. Nutrients. 2024;16(18):3148. doi:10.3390/nu16183148 2. Baden K, et al. Nutrients. 2024;16(21):3668. doi:10.3390/nu16213668 3. Papakostas GI, et al. Am J Psychiatry. 2012;169(12):1267-74. 4. Reynolds E. Lancet Neurol. 2006;5(11):949-60. 5. Kennedy DO. Nutrients. 2016;8(2):68.

One to two (1-2) capsules daily as a dietary supplement, or as directed by a Doctor. Best taken between meals.

Serving Size: 1 Capsule

Amount Per Serving

Vitamin B-6 ... 4 mg

(as Pyridoxal 5 Phosphate)

Folate ... 666 mcg

(400 mcg from L-5-Methylfolate, calcium salt)

Vitamin B-12 ... 1000 mcg

(as Methylcobalamin)

Calcium ... 54 mg

(as Calcium Cabonate)

Magnesium ... 20 mg

(as Magnesium Citrate)

SAMe ... 400 mg

(from 888 mg S-Adenosyl-L-methionine disulfate p-toluensulfonate, calcium chloride, calcium oxide)

Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine, silicon dioxide. 

If you are pregnant or lactating, have any health conditions or are taking any medication, consult your healthcare practitioner before use.