Saffron Extract 28mg

Saffron is sourced from the flower stigmas of Crocus sativus and has a history of use in traditional Ayurvedic medicine. Affron is a premium saffron ingredient standardized to 3.5% Lepticrosalides®, a complex of bioactive compounds including saffranal, crocin, and picrocrocin. Mood disorders are a pressing concern among today’s youth, and 28.3% of Canadian adults ages 35–49 find life on most days to be either quite a bit or extremely stressful. Saffron has been clinically shown to improve symptoms related to stress, anxiety, and low mood, along with enhancing sleep. Saffron acts on the hypothalamic pituitary adrenal (HPA) axis, a key player in the body’s stress response. Crocin and saffranal inhibit dopamine, norepinephrine, and serotonin reuptake in nerve synapses, increasing the concentration of these neurotransmitters within synapses and in the brain.

In a three-arm, placebo-controlled study, healthy adults with self-reported mood disorders were randomly assigned to take 28 or 22 mg of Affron or a placebo. After four weeks of supplementation, participants taking the 28 mg dose had a significant improvement in negative mood, perceived stress, and nervousness, compared to baseline. Improved symptoms included tension, sadness, anger, fatigue, confusion, vigour, and total mood disturbance. Similar benefits were seen in a controlled trial with adolescents aged 12–16. Affron also improved clinician-assessed scores of mood when combined with standard therapy. In a meta-analysis of 21 studies using saffron in individuals with mild-to-moderate mood disorders, participant scores on the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI) significantly improved, with a low incidence of side effects. Additionally, Affron has been shown to improve the sleep quality of participants with self-reported sleep problems and to increase evening melatonin levels

Suggested Use / Directions:

Adults (Mood, Symptoms of Stress, Nervousness, Sleep Quality): 1 capsule per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks. For sleep quality, consult a health care practitioner for use beyond 4 weeks.

Adolescents Over 12 Years of Age (Mood): 1 capsule per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 8 weeks.

Serving Size:
1 Vegetarian Capsule

Medicinal Ingredients:

Saffron Extract (affron®) (Crocus sativus) (stigma) ... 28 mg
(3.5% Lepticrosalides® containing crocins and safranal)

Non-Medicinal Ingredients:
vegetarian capsule (carbohydrate gum [cellulose], purified water, microcrystalline cellulose, vegetable grade magnesium stearate [lubricant], stearic acid, silica)

Caution: Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you suffer from any psychological disorder and/or condition, such as frequent anxiety or depression, or if you are taking antidepressants. Do not use if you are taking blood thinners/anticoagulants, have a bleeding disorder, or if you are pregnant or breastfeeding. Keep out of reach of children.

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.