Gemelli Biotech testing for practitioners: how to order through Fullscript
Access Gemelli Biotech testing within Fullscript. Order gastrointestinal and digestive health testing as part of your clinical workflow.
What is Gemelli Biotech
Gemelli Biotech develops at-home, mail-in gastrointestinal tests that measure breath gas patterns and antibody biomarkers that may aid in the assessment of small intestinal bacterial overgrowth (SIBO), intestinal methanogen overgrowth (IMO), intestinal sulfide overproduction (ISO), and post-infectious IBS.
When ordered through Fullscript, testing is integrated into the practitioner workflow and interpreted alongside patient history, symptoms, examination findings, and other clinical data.
Quick overview
Founded: 2018
Specialty: Gastrointestinal and digestive health testing
Use case: Integrative, functional, and primary care settings
Availability: U.S. (practitioner-ordered testing)
Support: Provider education and structured reporting
What is Gemelli Biotech
Gemelli Biotech develops at-home, mail-in gastrointestinal tests that measure breath gas patterns and antibody biomarkers that may aid in the assessment of small intestinal bacterial overgrowth (SIBO), intestinal methanogen overgrowth (IMO), intestinal sulfide overproduction (ISO), and post-infectious IBS.
When ordered through Fullscript, testing is integrated into the practitioner workflow and interpreted alongside patient history, symptoms, examination findings, and other clinical data.
Quick overview
Founded: 2018
Specialty: Gastrointestinal and digestive health testing
Use case: Integrative, functional, and primary care settings
Availability: U.S. (practitioner-ordered testing)
Support: Provider education and structured reporting
How Gemelli Biotech tests are used in clinical practice
Gemelli Biotech testing may be considered when additional gastrointestinal biomarker data is needed beyond standard laboratory evaluation.
Common clinical contexts include:
- Gastrointestinal symptoms such as bloating, gas, abdominal pain, constipation, or diarrhea
- Suspected small intestinal bacterial overgrowth (SIBO)
- Suspected intestinal methanogen overgrowth (IMO) or excess hydrogen sulfide
- Suspected post-infectious IBS following a food poisoning or GI infection event
- Suspected carbohydrate malabsorption
- Multi-system presentations involving the gut
Reports organize biomarkers into structured categories intended to support clinical interpretation alongside the broader clinical context.
Laboratory standards and technology
Types of Gemelli Biotech tests
Gemelli Biotech testing focuses on:
Breath-based gas testing for SIBO, IMO, and excess hydrogen sulfide
Carbohydrate malabsorption breath testing
Antibody-based blood testing for post-infectious IBS
Frequently ordered Gemelli Biotech tests
Laboratory findings should be interpreted alongside patient history, symptoms, physical examination, and other clinical data.
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Trio-Smart® SIBO Breath Test
A breath test that measures hydrogen, methane, and hydrogen sulfide in a single sample. These gases are associated with SIBO, intestinal methanogen overgrowth (IMO), and hydrogen sulfide patterns, which practitioners may review as part of their own assessment. The test uses a glucose substrate and at-home sample collection. Often considered in the evaluation of bloating, gas, abdominal pain, constipation, or diarrhea.
IBS-Smart® Test
A blood test that measures two antibodies (anti-CdtB and anti-vinculin) associated with post-infectious IBS, commonly the diarrhea-predominant and mixed subtypes. Practitioners may review these results alongside patient history and symptoms, particularly when there is a history of food poisoning or gastroenteritis. A negative result does not rule out IBS or other causes of chronic GI symptoms.
Trio-Smart® Malabsorption Breath Test
A breath test used to assess carbohydrate malabsorption with lactose, fructose, or sucrose substrates. Hydrogen patterns are used to support assessment of malabsorption, while methane and hydrogen sulfide levels are also reported, which practitioners may review alongside other clinical data.
Gemelli Biotech test selection and turnaround times
Turnaround times may vary and are not guaranteed*
Commonly used test | Specimen | Typical turnaround | |
|---|---|---|---|
| Suspected SIBO / IMO / ISO-related gas patterns | Trio-Smart® SIBO Breath Test | Breath | Typically 2–7 business days after sample receipt |
| Post-infectious IBS antibody markers | IBS-Smart® | Blood | Typically 2–7 business days after sample receipt |
| Carbohydrate malabsorption assessment | Trio-Smart® malabsorption breath testing | Breath | Typically 2–7 business days after sample receipt |
How Gemelli Biotech tests compare
How Trio-Smart compares to conventional breath testing
Many conventional SIBO breath tests measure hydrogen and methane. Trio-Smart adds hydrogen sulfide, which is associated with diarrhea and intestinal sulfide overproduction and is not captured by two-gas testing.
Hydrogen and methane breath testing is addressed in consensus guidance; hydrogen sulfide testing is a newer addition and should be interpreted in clinical context.
Conventional breath test | Trio-Smart | |
|---|---|---|
| Gases measured | Hydrogen, Methane | Hydrogen, Methane, Hydrogen Sulfide |
| Patterns assessed | SIBO, IMO | SIBO, IMO, excess hydrogen sulfide |
| Specimen | Breath | Breath |
| Collection | Varies | At home |
Why order Gemelli Biotech tests through Fullscript
Fullscript allows practitioners to incorporate Gemelli Biotech testing into an existing clinical workflow:
Streamline the lab ordering process within your existing clinical workflow
Send test kits directly to patients
Review results alongside other patient data
Access pricing information prior to ordering
Manage follow-up workflows within a single system
How to order Gemelli Biotech tests
Create a Fullscript account
Add a Gemelli Biotech test to a patient plan and send
Patients receive instructions for payment, shipping, and sample collection
Review results within your Fullscript dashboard
Frequently asked questions about Gemelli Biotech testing
Key takeaways
- Gemelli Biotech provides specialty testing focused on gastrointestinal and microbiome health
- Trio-Smart measures hydrogen, methane, and hydrogen sulfide
- IBS-Smart is a blood test that measures antibodies associated with post-infectious IBS
- Test selection is guided by clinical presentation and assessment goals
- Fullscript enables integration of testing into clinical workflows
Start ordering Gemelli Biotech tests
Create a Fullscript account to access Gemelli Biotech testing
This content is intended for licensed healthcare practitioners for educational purposes. Gemelli Biotech tests are laboratory tests ordered and interpreted by the practitioner as part of their own clinical assessment, alongside patient history, symptoms, and other clinical data. Test results are not a diagnosis. Fullscript does not interpret results or provide medical advice. References to conditions such as SIBO, IMO, ISO, and post-infectious IBS describe the biomarkers a test measures and do not represent a claim that the test diagnoses or confirms any condition.