The female reproductive system is a complicated
network that requires harmony between all
physiological systems to function properly. It relies
on, and is aected by, metabolic function,
cardiovascular function and the nervous system.
Any environmental changes that negatively impact
these systems can result in decreased female
reproductive health, including irregular menstrual
cycles, diminished ovulation and poor egg quality.
Cycle Matrix Ovulatory and Oocyte Support by
Cyto-Matrix combines a selection of natural health
ingredients to target and improve these
parameters in females experiencing irregular
menstrual cycles or other signs of hormonal
imbalance.
A common clinical picture of hormonal imbalance
in women is polycystic ovarian syndrome (PCOS).
Physiologically, women with PCOS present with
insulin resistance and subsequent elevations in
androgens and suboptimal progesterone during
the luteal phase of the menstrual cycle. This can
often result in irregular menses, excessive hair
growth, acne, weight gain and diculties with
conception. Fortunately, dietary modications,
lifestyle changes and a number of nutritional
supplements have been demonstrated to improve
this dysfunctional pattern. One great example of a
well-studied nutrient to benet PCOS is inositol.
Inositol is a naturally occurring isomer of glucose
and an important nutrient in the B-vitamin family.
It is a key component of the cellular membrane
and increases the sensitivity of cell receptors to
serotonin, acetylcholine, norepinephrine, thyroid
hormones and insulin. At doses of 1-4 grams/day,
inositol has been shown to improve insulin and
glucose control, regulate ovulation, improve egg
quality, lower androgens and improve fertility in
women with PCOS. When combined with folic acid,
inositol has been demonstrated to improve in
vitro fertilization (IVF) rates. Moreover, one study
found that this same combination of nutrients was
more eective at inducing ovulation and achieving
pregnancy in infertile women with PCOS when
directly compared to metformin.
On the topic of folate, even though it is classically
known for its importance in the rst trimester of
pregnancy to prevent neural tube defects like
spina bida and anencephaly, research has shown
that it also plays a crucial role in fertility and
pregnancy preparation. For example, studies have
found that higher folate levels are associated with
improved oocyte development, embryo quality
and implantation, clinical pregnancies and live
birth rates. In addition, research has found that
lower levels of folate may be accompanied with a
higher risk of early miscarriage. The high
prevalence of genetic modications in the 5-
MTHFR gene strongly suggests that 5-
methyltetrahydrofolate (5-MTHF), as opposed to
synthetic folic acid, is the necessary form for
supplementation in all women to ensure proper
absorption and utilization.
N-acetylcysteine (NAC) is another promising
treatment for PCOS. NAC is the rate-limiting
substrate needed for the production of
endogenous glutathione, one of our body’s most
powerful antioxidants and detoxifying
compounds. NAC has been used extensively in
clinical trials to support optimal health,
particularly in cases of liver protection and
respiratory conditions. In the context of women’s
health, NAC has been shown to improve insulin
sensitivity, restore ovulation and improve egg
quality in PCOS, while also signicantly increasing
the rate of live birth rates in women with
unexplained recurrent pregnancy loss. Finally,
NAC has been shown to improve pregnancy rates
when used adjunctively with clomiphene citrate in
intrauterine insemination (IUI) cycles for women
with unexplained infertility.
Mitochondrial dysfunction, as a result of any
number of environmental toxins, disease states or
ageing, is another identied mechanism behind
female hormonal imbalances and infertility. This
may explain why Coenzyme Q10 (CoQ10), a
nutrient known to support mitochondrial function
and increase ATP energy production, has shown
such promise in various female infertility cases.
Although CoQ10 has classically been used as a
cardiovascular nutrient, recent research has
shown that CoQ10 improves conception rates by
supporting egg quality, embryo implantation and
embryonic growth. Pyrroloquinoline quinone
(PQQ) is a unique antioxidant that has been
shown to have synergistic benecial eects on
mitochondrial function when used alongside
CoQ10.
In some cases of infertility, the health of the
endometrial lining may be a contributing concern
and L-arginine may be helpful. L-arginine has been
supplemented principally for its ability to
upregulate nitric oxide and improve blood ow,
explaining its benets on intermittent claudication
and exercise performance, but it also has
demonstrated merit for women’s health.
Increased nitric oxide supports blood ow to the
pelvic organs, supporting endometrial receptivity,
endometrial thickness and follicular growth. One
particular study found that L-arginine improved
endometrial thickness and pregnancy rates in
women with thin endometrial linings.
Finally, select cases of menstrual irregularities
may be linked back to low progesterone levels,
independently of PCOS. Vitex agnus-castus,
commonly known as Chastetree, has long been
used for raising progesterone levels and
addressing women’s health concerns. Diterpene
compounds and avonoids found in vitex have
been demonstrated to exhibit dopaminergic
action, thereby reducing prolactin levels and
increasing endogenous progesterone. Collectively,
these actions would explain why clinical research
has found that vitex can improve menstrual cycle
regularity and PMS symptoms.
Cycle Matrix Ovulatory and Oocyte Support
combines all of these evidenced based nutrients
to support women’s fertility including ovulation,
oocyte quality, embryonic development and
successful gestation. Plus, additional choline to
positively inuence fetal brain and spinal cord
formation. Cycle Matrix Ovulatory and Oocyte
Support is oered in a convenient peach mango
avoured powder for improved compliance and
ease of use. Each 276 gram bottle contains a 30
day supply. Cycle Matrix Ovulatory and Oocyte
Support is vegan and free from GMOs, gluten, soy
and dairy.
Suggested Use:
Adult women - Take 1 scoop per day in water or juice or as directed by a healthcare professional. Take with food. 400 mcg of folate per day is adequate for most women (to reduce the risk of neural tube defects). Consult a healthcare professional to determine if you would benefit from additional folate before taking this product.
Duration of Use: At a minimum, women who are planning to become pregnant should start taking this supplement 3 months before the pregnancy. Consult a healthcare professional for use beyond 6 weeks if you suffer from a cardiovascular disease.
Ingredients:
Myo-Inositol (inositol) … 4 g
L-Arginine (as L-arginine monohydrochloride) … 1 g
N-Acetyl-L-Cysteine … 600 mg
Choline (as choline L(+)-bitartrate [VitaCholine®]) … 650 mg
Coenzyme Q10 … 300 mg
Chaste Tree (Vitex agnus-castus, fruit) extract (10:1) … 50 mg
Equivalent to 500 mg dried fruit
PQQ (pyrroloquinoline quinone disodium salt) … 20 mg
Folate (as calcium L-5-methyltetrahydrofolate) … 1000 mcg
Non-Medicinal Ingredients: Beetroot powder, beta-carotene, citric acid, malic acid, silicon dioxide, stevia, maltodextrin, natural peach flavour, natural mango flavour
Do not use if you are taking antibiotics, nitroglycerin, are pregnant or breastfeeding, have had a heart attack (myocardial infarction), or are attempting to conceive unless directed by a healthcare professional.
Consult a healthcare professional prior to use if you have kidney stones, cardiovascular disease, or are increasing physical activity, or if your cardiovascular condition worsens.
Consult a healthcare professional prior to use if you are taking medications for cardiovascular disease, erectile dysfunction, blood pressure, blood thinning, or hormone-containing therapies such as progesterone, oral contraceptives, or hormone replacement therapy.
Consult a healthcare professional if migraine frequency increases or if associated nausea and vomiting persist or worsen, or if symptoms persist or worsen.
400 mcg of folate per day is adequate for most women to reduce the risk of neural tube defects. Consult a healthcare professional to determine if additional folate is needed before use.
When using this product, you may experience gastrointestinal discomfort such as diarrhea.
Keep out of reach of children.
