Tricycline

Support Balanced Microbial Ecology in the GI Tract*

What It Does
Tricycline® is a microbial balancing formula designed to support a healthy gastrointestinal (GI) microbiome.* It complements probiotic use by promoting a balanced microbial environment and healthy intestinal function.* This unique botanical blend offers targeted support for digestive health and intestinal microbial ecology.*

How It Works
•    Berberine: A bioactive alkaloid that supports digestive function and modulates the gut microbiome toward a favorable balance, encouraging short-chain fatty acid production and healthy mucosal integrity.*[1]
•    Artemisinin (from Artemisia annua): A highly concentrated form of sweet wormwood shown to influence GI microbial composition via multiple mechanisms; independently tested for cell activity and potency via third-party HPLC.*[4]
•    Citrus Seed Extract (Grapefruit): Contains polyphenols such as naringenin, which may influence gut motility and intestinal barrier function while promoting microbial diversity in the proximal colon.*[5-7]
•    Black Walnut Hulls: Traditionally used to support skin and GI health; a source of tannins and antioxidant compounds with microbial-modulating effects.*[8]
•    Sweet Wormwood (Artemisia annua): A traditional herb used for microbial balance, providing additional phytochemical support to the artemisinin content.*

Who It’s For
Ideal for individuals seeking additional gastrointestinal support beyond probiotics, particularly those with concerns about microbial balance, gut motility, or intestinal immune tone.*

Special Features
Tricycline® features independently verified artemisinin potency, third-party HPLC testing, and a comprehensive blend of traditional and modern microbiome-focused botanicals. It is formulated without unnecessary fillers or allergens.

References
1.    Xu X, et al. Biomed Pharmacother. 2021;133:110984. doi:10.1016/j.biopha.2020.110984
2.    Caliceti C, et al. Curr Med Chem. 2016;23(14):1460-76.
3.    Zhang L, et al. Front Cell Infect Microbiol. 2021;10:588517. doi:10.3389/fcimb.2020.588517
4.    Golenser J, et al. Int J Parasitol. 2006;36(14):1427-41.
5.    Sost MM, et al. Nutrients. 2021;13(11):3915. https://doi.org/10.3390/nu13113915
6.    Wu L, et al. Foods. 2024;13(16):2520. https://doi.org/10.3390/foods13162520
7.    Stevens Y, et al. Nutrients. 2019;11(7):1464. https://doi.org/10.3390/nu11071464
8.    Jahanban-Esfahlan A, et al. Int J Mol Sci. 2019;20(16):3920. doi:10.3390/ijms20163920
9.    Wenzel J, et al. Food Sci Nutr. 2016;5(2):223-32.

As a dietary supplement, 1 or 2 capsules two or three times daily with meals, or as directed by a healthcare practitioner. Artemisinin is best taken as part of a program that includes appropriate liver support nutrients.

Serving Size: 2 capsules

Amount Per Serving
Berberine Sulfate ... 400mg
Artemisinin ... 60mg
Citrus Seed Extract ... 400mg
Black Walnut Hulls ... 100mg

Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine.

CAUTION: Not indicated for pregnant or nursing women. It may be wise to work with a healthcare practitioner to monitor liver enzymes and hemoglobin when using this product. Combining with antioxidants or iron may theoretically decrease effectiveness. Detoxification reactions may be experienced by some individuals. In rare cases may cause idiosyncratic liver dysfunction.

Variations in product color may occur. Keep in a cool, dry place, tightly capped.