Innate Response Protocol

Adrenal Health

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This protocol was developed for practitioners using Fullscript in Canada and the templates cannot be applied to accounts operating outside of Canada.

Disclaimer

This protocol is produced by TallGrass Natural Health. TallGrass Natural Health is the exclusive Canadian distributor of Innate Response, MegaFood, Host Defense, Renew Life, and the manufacturer of Botanica.

Innate Response

One of the four following: (Adrenal Response Complete Care, Adrenal Support Liquid Capsules, Adrenal Support Compounds Liquid Herb, MycoBotanicals Stress Decompress)

Adrenal Response Complete Care

2 tablets daily

Blend of nutrients and botanicals to nourish depleted adrenals, ward off fatigue, and promote a healthy stress response by the body.

Contains Sensoril®, a patented extract of Ashwagandha root and leaf that has been clinically shown to strengthen the body against the adverse effects of chronic stress. (1) Sensoril® Ashwagandha has a high withanolide content (8%) which allows for a stronger herbal formula and can avoid the need for a glandular extract. Rhodiola is a stimulating herb and helps us to better cope with the demands of stress in our lives, helping us feel less tired and overwhelmed. It is ideal if you need an energizing boost (2) for both the brain and body. Holy Basil is calming for the mind and nervous system. (3) It can help reduce mental fog associated with chronic stress and improve mental clarity. (4) Best choice for combined whole food nutritional and botanical adrenal support in tablet form. (Can choose Adrenal Response if prefer to work only with botanicals.)

B Complex

1 capsule daily

Because B vitamins are best obtained from food sources, FoodState Nutrients provide a unique solution to these dietary deficiencies by providing vitamins delivered with whole food for optimal phytonutrient synergy and bioavailability. 

B Vitamins are necessary to convert food into cellular energy and support nervous system health.

C Complete Powder

1 capsule daily

1000mg of Vitamin C offered as a blend of FoodState® vitamin C, paired with mineral ascorbates for optimal absorption, along with a phenolic-rich food blend high in antioxidants and bioflavonoids. C Complete Powder is naturally buffered and therefore gentle on the stomach and less acidic than vitamin C alone.  

The adrenal gland is among the organs with the highest concentration of vitamin C in the body. Ascorbic acid is a cofactor required both in catecholamine biosynthesis and in adrenal steroidogenesis. (8) As such, this premier biologically active formula is an excellent choice to promote overall wellness, cellular health and support a  healthy immune response, especially in times of stress. 

Host Defense Mushrooms

Click to view Host Defense Mushrooms protocols

One of the four following: (Adrenal Response Complete Care, Adrenal Support Liquid Capsules, Adrenal Support Compounds Liquid Herb, MycoBotanicals Stress Decompress)

MycoBotanicals Stress Decompress

2 capsules daily

Combines mushrooms and herbs to reduce the sympathetic nervous system while gently energizing the body and mind.

Reishi supports adrenal function while calming the fight or flight response. Lion’s Mane supports a balanced mood. Skullcap helps calm overactive mind while Ashwagandha helps the adaptation to stress and balances cortisol. Lemon Balm promotes a calm and relaxed mind. Best choice if seeking the synergistic effect of a mushroom and botanical blend.

Cordychi Capsules or Liquid Extract

2 capsules daily or 1 mL, two times daily

Medicinal mushrooms reishi and cordyceps to promote a healthy response to stress factors and to enhance energy and oxygen uptake.

Reishi has been shown to reduce the sympathetic nervous system (11) without being sedating. Reishi supports endurance and muscle function, increasing our physical response to stressors while simultaneously reducing the neurological hyper-arousal that occurs under stressful situations.

Botanica

Click to view Botanica protocols

One of the four following: (Adrenal Response Complete Care, Adrenal Support Liquid Capsules, Adrenal Support Compounds Liquid Herb, MycoBotanicals Stress Decompress)

Adrenal Support Liquid Capsules

2 capsules daily, two times daily

Convenient capsules with the concentration of liquid botanicals provide adaptogenic support to the adrenals to help manage both the physical and emotional effects of stress. Each of Botanica’s liquid capsules contains 75 drops of a 1:1 fluid extract. The average tinctures on the market are generally a dilution of 1:3 to 1:6. One Botanica capsule is roughly equivalent to 350 drops of an average tincture (will vary with which dilution it is being compared to). 

Eleuthero is an excellent but mild adaptogen, (5) which normalizes blood pressure and immune activity, and reduces fatigue, stress, and depression. Ashwagandha is a wonderful overall tonic to help boost energy reserves and promote health. In particular, Ashwagandha is a powerful adaptogen to help one adapt to the challenges and demands of stress (6), supporting our vitality and energy. Traditionally, Ashwagandha was used in cases of nervous exhaustion and long-term stress, a case of an overactive but debilitated person, and so it is wonderful to support when you are feeling tired but wired. Schisandra also supports the body’s natural resistance to stress but has an unusual dual effect on the nervous system. It has a mild stimulating effect to enhance reflexes, work performance, and mental activity, but will also calm and help relieve anxiety. The formula also includes milky oat seed and holy basil for additional nervous system support. Best choice if seeking benefits of concentrated liquid botanicals in an easy and convenient capsule form. Often used in chronic cases. 

Adrenal Support Compounds Liquid Herb

2-3 mL, up to three times daily

Botanical tincture for easy individualized dosing provides botanical support to the adrenals to help manage both the physical and emotional effects of stress.

Spagyric extraction process: all plant constituents are dissolved into the solvent, the unused plant matter is then separated out and reduced to white ash. This matter is then rejoined with the original extract, thus maintaining all the valuable minerals present in the plant’s natural state. Includes devil’s club for additional blood sugar support. Best choice for easy individualized drop dosing for acute care or sensitive individuals.  

Perfect Greens – Unflavoured

1 scoop daily 

A clean, organic blend of chlorella, spirulina, barley, and wheat grasses plus leafy greens to help top up and ensure that you are getting your greens. Very high greens content at 7435 mg per serving as well as 591 mg of antioxidant superfoods. Rich in prebiotics to support healthy bowels and helps to alkalize, detoxify, and energize. 

Cereal grasses such as Barley grass, Oat grass, and Wheatgrass, are packed with essential vitamins and minerals. They are a rich source of chlorophyll, a potent antioxidant. Cereal grasses also offer unique digestive enzymes that are not found in such concentrations in most other foods. In particular, they contain Super Oxide Dismutase (SOD), a powerful antioxidant that is highly valued for its ability to slow the aging process, as well as the degenerative process of many chronic diseases. Gluten-free – but not third-party tested for celiacs.

Botanica Perfect Greens Product Sheet

Perfect Protein Elevated – Adrenal Support

1 scoop daily

Organic plant protein blended with adrenal-supporting superfoods and botanicals (Ashwagandha, Reishi, and Acerola cherry for the source of Vitamin C) to support energy levels, resistance to stress, and overall immune function. All ingredients are in their whole food form. We have not isolated the protein but have concentrated it via natural enzymatic processes. 

Convenient choice if wanting daily adrenal support along with optimal plant-based protein supplementation. Reishi is a whole-body adaptogen, it is known to help support a healthy stress response. It is nourishing to the adrenals (our stress glands) as well as to the nervous & cardiovascular (9) systems. Reishi helps to modulate and balance immune function & inflammation. Ashwagandha is a wonderful overall tonic to help boost energy reserves and promote health. In particular, Ashwagandha is a  powerful adaptogen to help one adapt to the challenges and demands of stress, (5) supporting our vitality and energy. Traditionally, Ashwagandha was used in cases of nervous exhaustion and long-term stress, a case of an overactive but debilitated person, and so it is wonderful support when you are feeling tired but wired. Acerola cherries are rich in antioxidants & naturally occurring vitamin C (100% bioavailable). They provide nourishment to the adrenal glands which burn more vitamin C when under stress. A vegan-friendly formula. Gluten-free – but not third-party tested for celiacs. 

Botanica Perfect Protein Product Sheet

Fermented Ashwagandha 

2 tbsp daily 

A dose of a fermented ashwagandha to help balance adrenals and promote gut health; loaded with enzymes, B vitamins, micronutrients, and organic acids for gut repair.

Fermented herbs offer whole body support with easy to absorb nutrients that can assist in assimilation and stomach acid production, support proper pH and intestinal villi, and act as a source of probiotics. Ashwagandha is a powerful adaptogen to help one adapt to the challenges and demands of stress, supporting our vitality and energy. Traditionally, Ashwagandha was used in cases of nervous exhaustion and long-term stress, a case of an overactive but debilitated person, and so it is a wonderful  support when you are feeling tired but wired.

MegaFood

Click to view MegaFood protocols

Magnesium

Highly absorbable FoodState magnesium synergistically paired with organic whole food spinach to nourish adrenal glands and support the nervous system. 

Despite being one of the most abundant minerals in the human body, more than half of adults in the United States do not consume the estimated average requirement for magnesium, according to data from a 2009 NHANES study. (7) Magnesium is often very low in those with hormonal imbalances (adrenal fatigue and thyroid disorder) and is one of the most supportive minerals to take during times of increased stress. 

References

  1. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Chandrasekhar K, Kapoor J, Anishetty  S. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022
  2. Stress management and the role of Rhodiola rosea: a review. Anghelescu IG, Edwards D, Seifritz E, Kasper S. Int J Psychiatry Clin Pract. 2018 Nov;22(4):242-252. doi: 10.1080/13651501.2017.1417442. Epub 2018 Jan 11. PMID: 29325481.
  3. Anti-stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic-Pituitary-Adrenal Axis. Jothie Richard E, Illuri R, Bethapudi B, Anandhakumar S, Bhaskar A, Chinampudur Velusami C, Mundkinajeddu D, Agarwal A. Phytother  Res. 2016 May;30(5):805-14. doi: 10.1002/ptr.5584. Epub 2016 Feb 22. PMID: 26899341.
  4. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Sampath S, Mahapatra SC, Padhi MM, Sharma R, Talwar A. Indian J Physiol Pharmacol. 2015  Jan-Mar;59(1):69-77. PMID: 26571987.
  5. Antioxidant evaluation of three adaptogen extracts. Chen TS, Liou SY, Chang YL. Am J Chin Med. 2008;36(6):1209-17. doi: 10.1142/S0192415X08006533. PMID: 19051347.
  6. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Medicine  (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.
  7. What We Eat in American NHANES 2005-2006, Usual Nutrient Intakes from Food And Water Compared to 1997 Dietary Reference, A Moshfegh et al.
  8. Patak P, Willenberg HS, Bornstein SR. Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocr Res. 2004 Nov;30(4):871-5. doi: 10.1081/erc-200044126. PMID: 15666839.
  9. Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain. Phytomedicine. Shevelev OB, Seryapina AA, Zavjalov EL, Gerlinskaya LA, Goryachkovskaya TN,  Slynko NM, Kuibida LV, Peltek SE, Markel AL, Moshkin MP. 2018 Mar 1;41:1-6. doi: 10.1016/j.phymed.2018.01.013. Epub 2018 Jan 31. PMID: 29519314.
  10. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Medicine  (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.
  11. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Lee SY, Rhee HM. Chem Pharm Bull (Tokyo). 1990 May;38(5):1359-64. doi: 10.1248/cpb.38.1359. PMID: 2393962.
  12. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Medicine  (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.

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The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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