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Digestive Wellness

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Digestive Wellness

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through C-quality evidence.

Systematic review or meta-analysis of human trials
RDBPC human trials
2+ studies and/or 1 study with 50 + subjects
RDBPC human trials
1 study

Peppermint oil

0.1-0.3 mL (or 200 mg), three times per day1,2,3,4,5

  • Significant reduction of abdominal pain and global symptoms, relative to placebo6
  • Benefits no longer present two weeks after supplement cessation6
Peppermint oil in the Fullscript catalog

Soluble dietary fiber

20-35 g of long-chain, intermediate viscous, soluble and moderately fermentable dietary fiber7

  • Safe and effective in improving global IBS symptoms, relative to placebo8
  • Form of soluble fiber used is important, since short-chain soluble and highly fermentable dietary fiber can result in rapid gas production that can aggravate symptoms in patients with IBS8
Fiber in the Fullscript catalog


25-50 billion CFU, one to three times per day10

  • Effective in reducing symptoms and severity score in patients with IBS10
  • Specific strain recommendations remain to be concluded11,12
  • Current recommendations suggest using an equal dosage of lactobacillus and bifidobacterium species12
Probiotics in the Fullscript catalog


0.25 g/kg of weight, once per day, minimum 14 days15,16

  • Glutamine has shown to improve intestinal permeability13,14,15,16
  • Acute glutamine administration has been linked to a decrease of gastro-intestinal symptoms and improvement in intestinal permeability in athletes competing in heat15
L-Glutamine in the Fullscript catalog


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials
Systematic review or meta-analysis of human trials

Fullscript content philosophy

At Fullscript, we are committed to curating accurate, and reliable educational content for practitioners and patients alike. Our educational offerings cover a broad range of topics related to integrative medicine, such as supplement ingredients, diet, lifestyle, and health conditions.

Medically reviewed by expert practitioners and our internal Integrative Medical Advisory team, all Fullscript content adheres to the following guidelines:

  1. In order to provide unbiased and transparent education, information is based on a research review and obtained from trustworthy sources, such as peer-reviewed articles and government websites. All medical statements are linked to the original reference and all sources of information are disclosed within the article.
  2. Information about supplements is always based on ingredients. No specific products are mentioned or promoted within educational content.
  3. A strict policy against plagiarism is maintained; all our content is unique, curated by our team of writers and editors at Fullscript. Attribution to individual writers and editors is clearly stated in each article.
  4. Resources for patients are intended to be educational and do not replace the relationship between health practitioners and patients. In all content, we clearly recommend that readers refer back to their healthcare practitioners for all health-related questions.
  5. All content is updated on a regular basis to account for new research and industry trends, and the last update date is listed at the top of every article.
  6. Potential conflicts of interest are clearly disclosed.