Designs for Health Protocol

Women’s Hormonal Balancing

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Supporting healthy hormone balance

Maintaining a healthy hormonal balance is critical to overall wellness. Hormones orchestrate complex and interconnected aspects of physiology which, if unbalanced, can lead to dysfunction in the presenting patient. Conditions characterized by hormonal imbalance are common in female patient populations. Perturbations in androgen activity, estrogen metabolism, and hormone detoxification/elimination can result in an array of symptoms and impaired function. Imbalances in hormone synthesis and activity may manifest in a range of conditions for women, including estrogen dominance, PCOS, hirsutism, androgen excess, PMS, dysmenorrhea, and infertility. This protocol is designed to support healthy female hormone balance and activity, with a specific focus on estrogen metabolism.

Lifestyle interventions

  • Recommend stress management techniques to support a healthy hypothalamic–pituitary–adrenal (HPA) axis and hypothalamic–pituitary–gonadal axis (HPG) axis
  • Promote moderate physical activity; counsel on avoidance of overtraining to prevent impact on cortisol activity and HPA axis
  • Recommend avoidance of potential xenoestrogens and endocrine disruptors (ex. phthalates, parabens, bisphenol A (BPA), etc.) through consumption of organic foods, use of chemical-free personal care products and household cleaners

Therapeutic diet and nutrition considerations

  • Recommend high intake of cruciferous vegetables (bok choy, broccoli, Brussels sprouts, cabbage, cauliflower, horseradish, kale, kohlrabi, mustard, radish, rutabaga, turnip, and watercress) for consumption of isothiocyanates
  • Ensure adequate intake of fiber (25-30g/day) to support stable blood sugar levels and elimination of hormone metabolites
  • Recommend patients consume a low-glycemic diet
  • Ensure adequate zinc intake (8mg/day; 11mg/day during pregnancy; 12mg/day during lactation) through rich sources such as oysters, liver, beef, pork, crab, lobster, baked beans, egg yolks. Zinc plays a role in endocrine function via the metabolism of androgen hormones, estrogen, and progesterone, together with the prostaglandins, and a role in the secretion of insulin (2)
  • Moderate alcohol & caffeine intake

Diagnostic biomarkers/clinical indicators

  • Consider estrogen metabolite/estrogen ratio testing, and monitoring for hypoglycemia, hypothyroidism, adrenal insufficiency, insulin levels, abnormal blood glucose (HA1C), LFTs (liver function tests), GGT (glutathione), estrogen metabolite ratio testing, zinc status (alkaline phosphatase)
  • GenomicInsight® – Estrogen Genomics
Primary Support:


2 capsules with breakfast and 2 with dinner (4 capsules per day), ongoing to support proper hormone metabolism 

FemGuard+Balance™ supports classic herbal hormonal balancing in the form of vitex, polygonum, and black cohosh, along with DIM and chrysin for protection and support of beneficial estrogen aromatase activity. Calcium-D-glucarate promotes the proper elimination of excess estrogens. Resveratrol and EGCg from green tea are included for maximum antioxidant protection. Vitamins B6, B12, and folate promote proper cell differentiation. Magnesium and calcium are also included to help support bone and hormone health.*


1-2 softgels per day, ongoing to support proper hormone metabolism 

Supports Healthy Sleep Cycle & Supports Gastrointestinal Health*

DIM-Evail™ provides 100 mg per softgel of diindolylmethane (DIM), a compound that helps to support healthy estrogen metabolism.* Due to its crystalline structure, absorption of DIM is minimal when given orally. For this reason, DIM-Evail™ has been manufactured utilizing the proprietary Designs for Health Evail™ process, which improves the absorption of DIM. This process utilizes a proprietary blend of MCT oils, non-soy derived lecithin, and vitamin E without the use of potentially harmful surfactants. Research tells us that a low level of the 2-hydroxyestrone and a high level of 16 alphahydroxyestrone are not desired. DIM works by helping to increase 2-hydroxyestrone and therefore improves the 2/16 hydroxyestrone ratio.*


1 capsule, ongoing to support proper hormone metabolism and detoxification

BroccoProtect™ is a synergistic blend of specially cultivated broccoli seed extract and broccoli sprout concentrate, providing sulforaphane glucosinolate and myrosinase enzyme for maximal conversion to broccoli’s beneficial compound, sulforaphane. It is offered in a delayed-release capsule in order to further optimize this conversion and maximize bioavailability. BroccoProtect™ is designed to help support detoxification, antioxidant status, and cellular health, as well as offer cardiovascular and neuronal protection.*

Adjunct Support:

Zinc Supreme™

1 capsule per day with a meal, ongoing to support proper hormone metabolism

Zinc Supreme™ offers chelated minerals by Albion Advanced Nutrition, the leader in mineral technology. These are ideal chelates with a 2:1 molar ratio of two molecules of the amino acid glycine chemically bonded in liquid to one mineral ion of zinc or molybdenum for optimal absorption. These minerals are combined with other nutrients such as vitamin B6 and taurine to provide superior results.


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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  1. Fuhrman BJ, Schairer C, Gail MH, Boyd-Martin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG. Estrogen metabolism and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 2012;15:326–329. doi: 10.1093/jnci/djr531.
  2. Ann Katrin Sauer, Simone Hagmeyer and Andreas M. Grabrucker (July 20th 2016). Zinc Deficiency, Nutritional Deficiency, Pınar Erkekoglu and Belma Kocer-Gumusel, IntechOpen, DOI: 10.5772/63203. Available from:

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