This protocol was developed to support general wellness as well as bone, cardiovascular, hormonal, and microbiome health in women over 50 years of age. This protocol features key women’s health products from Metagenics, one of our many supplement brand partners who are committed to using evidence-based ingredient formulations and maintaining high-quality supplement standards.

Key ingredients included in the protocol

Calcium May help support healthy blood pressure (3) and bone health (18)
Omega-3 fatty acids May help support healthy blood pressure (7) and cholesterol levels, (5) cognitive function, (22) mental health, (20) and hormonal balance (14) 
Magnesium  May help support healthy blood pressure (4) and sugar levels, (9) as well as bone, (1) muscle, (19) and mental health (13)
Multivitamin May help support cellular health, (21) cognitive function, (16) and mental health (15)
Rhubarb extract ERr 731® Long-term use (> 48 weeks) may help support hot flashes with no clinically significant adverse events (10)
Vitamin D May help support many aspects of health such as bone health, (2) blood pressure, (8) blood sugar, (11) cognitive function, (17) mental health, (12) and longevity (23) 
Vitamin K May help support bone health (6)

Wellness Essentials® Women’s Prime (daily pack)

Each daily pack contains the following:

  • PhytoMulti tablet
      • 1 green tablet, once per day, for 3 weeks
      • Multivitamin with a proprietary blend of 13 concentrated extracts and phytonutrients for general wellness support* 
  • OmegaGenics EPA-DHA 500
      • 2 golden yellow softgels, once per day, for 3 weeks
      • EPA and DHA for cardiovascular, immune, and general wellness support*
  • Ostera
      • 2 yellow tablets, once per day, for 3 weeks
      • Vitamin D and K formulation for bone health support* 
  • Bone Builder with Magnesium
    • 2 off-white tablets, once per day, for 3 weeks
    • Multimineral and vitamin D formulation for bone health support* 

UltraFlora® Women’s

  • 1 capsule, once per day, for 3 weeks
  • Probiotics strains for healthy vaginal microflora and urogenital health*


  • 1 capsule, once per day, for 3 weeks
  • Rhubarb root for healthy estrogen levels*


The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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  1. Aydin, H., Deyneli, O., Yavuz, D., Gözü, H., Mutlu, N., Kaygusuz, I., & Akalin, S. (2010). Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biological Trace Element Research, 133(2), 136–143. 
  2. Chakhtoura, M., Chamoun, N., Rahme, M., & Fuleihan, G. E.-H. (2020). Impact of vitamin D supplementation on falls and fractures – A critical appraisal of the quality of the evidence and an overview of the available guidelines. Bone, 131, 115112. 
  3. Cormick, G., Ciapponi, A., Cafferata, M. L., & Belizán, J. M. (2015). Calcium supplementation for prevention of primary hypertension. Cochrane Database of Systematic Reviews , 6, CD010037. 
  4. Dibaba, D. T., Xun, P., Song, Y., Rosanoff, A., Shechter, M., & He, K. (2017). The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: A meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 106(3), 921–929. 
  5. Eslick, G. D., Howe, P. R. C., Smith, C., Priest, R., & Bensoussan, A. (2009). Benefits of fish oil supplementation in hyperlipidemia: A systematic review and meta-analysis. International Journal of Cardiology, 136(1), 4–16. 
  6. Fang, Y., Hu, C., Tao, X., Wan, Y., & Tao, F. (2012). Effect of vitamin K on bone mineral density: A meta-analysis of randomized controlled trials. Journal of Bone and Mineral Metabolism, 30(1), 60–68. 
  7. Geleijnse, J. M., Giltay, E. J., Grobbee, D. E., Donders, A. R. T., & Kok, F. J. (2002). Blood pressure response to fish oil supplementation: Metaregression analysis of randomized trials. Journal of Hypertension, 20(8), 1493–1499. 
  8. Golzarand, M., Shab-Bidar, S., Koochakpoor, G., Speakman J, R., & Djafarian, K. (2016). Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis. Nutrition, Metabolism, and Cardiovascular Diseases, 26(8), 663–673. 
  9. Guerrero-Romero, F., Simental-Mendía, L. E., Hernández-Ronquillo, G., & Rodriguez-Morán, M. (2015). Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: A double-blind placebo-controlled randomized trial. Diabetes & Metabolism, 41(3), 202–207. 
  10. Hasper, I., Ventskovskiy, B. M., Rettenberger, R., Heger, P. W., Riley, D. S., & Kaszkin-Bettag, M. (2009). Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause , 16(1), 117–131. 
  11. He, S., Yu, S., Zhou, Z., Wang, C., Wu, Y., & Li, W. (2018). Effect of vitamin D supplementation on fasting plasma glucose, insulin resistance and prevention of type 2 diabetes mellitus in non-diabetics: A systematic review and meta-analysis. Biomedical Reports, 8(5), 475–484. 
  12. Jorde, R., Sneve, M., Figenschau, Y., Svartberg, J., & Waterloo, K. (2008). Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: Randomized double blind trial. Journal of Internal Medicine, 264(6), 599–609. 
  13. Li, B., Lv, J., Wang, W., & Zhang, D. (2017). Dietary magnesium and calcium intake and risk of depression in the general population: A meta-analysis. The Australian and New Zealand Journal of Psychiatry, 51(3), 219–229. 
  14. Lucas, M., Asselin, G., Mérette, C., Poulin, M.-J., & Dodin, S. (2009). Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women: A double-blind, placebo-controlled, randomized clinical trial. Menopause , 16(2), 357–366. 
  15. Macpherson, H., Rowsell, R., Cox, K. H. M., Scholey, A., & Pipingas, A. (2015). Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: A randomised controlled trial. Age , 37(3), 9782. 
  16. Macpherson, H., Silberstein, R., & Pipingas, A. (2012). Neurocognitive effects of multivitamin supplementation on the steady state visually evoked potential (SSVEP) measure of brain activity in elderly women. Physiology & Behavior, 107(3), 346–354. 
  17. Miller, B. J., Whisner, C. M., & Johnston, C. S. (2016). Vitamin D supplementation appears to increase plasma Aβ40 in vitamin D insufficient older adults: A pilot randomized controlled trial. Journal of Alzheimer’s Disease, 52(3), 843–847. 
  18. Nordin, B. E. C. (2009). The effect of calcium supplementation on bone loss in 32 controlled trials in postmenopausal women. Osteoporosis International, 20(12), 2135–2143. 
  19. Roffe, C., Sills, S., Crome, P., & Jones, P. (2002). Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Medical Science Monitor, 8(5), CR326–CR330. 
  20. Sublette, M. E., Ellis, S. P., Geant, A. L., & Mann, J. J. (2011). Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. The Journal of Clinical Psychiatry, 72(12), 1577–1584. 
  21. Xu, Q., Parks, C. G., DeRoo, L. A., Cawthon, R. M., Sandler, D. P., & Chen, H. (2009). Multivitamin use and telomere length in women. The American Journal of Clinical Nutrition, 89(6), 1857–1863. 
  22. Yurko-Mauro, K., Alexander, D. D., & Van Elswyk, M. E. (2015). Docosahexaenoic acid and adult memory: A systematic review and meta-analysis. PloS One, 10(3), e0120391. 
  23. Zheng, Y., Zhu, J., Zhou, M., Cui, L., Yao, W., & Liu, Y. (2013). Meta-analysis of long-term vitamin D supplementation on overall mortality. PloS One, 8(12), e82109.