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Cardiovascular Health – Cholesterol Support

Protocols Fullscript Protocols
Cardiovascular Health – Cholesterol Support

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

As a result, the Fullscript Integrative Medical Advisory team advises using an evidence-informed approach to protocol development. To simplify this process for practitioners, we have assembled a sampling of evidence-based standardized protocols that practitioners can use as a foundation when developing individualized protocols.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through D-quality evidence. These are categorized as follows:

Class Qualifying studies Minimum requirements
A Systematic review or meta-analysis of human trials
B Human RDBPC ≥ 2 studies and/or 1 study with ≥ 50
subjects
C Human RDBPC or RCT 1 study < 50 subjects
D Human trials or In-vivo animal trials

RDBPC = Randomized Double-Blind Placebo Controlled
RCT = Randomized Controlled Trials

Please refer to the complete Rating Scale for further information.

Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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Cardiovascular Health – Cholesterol Support

Red Yeast Rice (Monascus purpureus)

1200-2400mg, once per day, minimum 8 to 12 weeks1

  • Decrease in LDL, total cholesterol and homocysteine1,2,3
  • 10 mg of Monacolins K (constituent of Red Yeast Rice) was shown to decrease LDL-C2
  • Red Yeast Rice has been shown to be as effective as simvastatin for its capacity to lower lipids4
Red Yeast Rice in the Fullscript catalog.

Coenzyme Q10 (CoQ10)

200mg, once per day, minimum 3 months5

  • CoQ10 has been shown to reduce total cholesterol and LDL, and increase HDL5,6
  • Reduction in triglyceride levels observed with consistent supplementation7
Coenzyme Q10 (CoQ10) in the Fullscript catalog.

Omega 3 Fatty Acids

2.52g, total per day, minimum 3 months8

  • By reducing VLDL, both EPA and DHA when administered independently resulted in reduced fasting circulating triglyceride levels9
  • DHA has shown to have a greater impact in decreasing triglycerides and increasing HDL10
Omega 3 Fatty Acids in the Fullscript catalog.

Garlic (Allium sativum)

400-600mg, once per day, minimum 12 weeks11,12

  • Decrease in LDL (low density lipoprotein) and total cholesterol was observed 13,14,15
  • Increase in HDL (high density lipoprotein) in addition to a decrease in alipoprotein B and an increase in the LDL/alipoprotein B ratio was observed16
Garlic (Allium sativum) in the Fullscript catalog.

References

1
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761143/
3
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/25897793
4
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/26956355
6
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/30296936
7
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/25913756
9
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/28797250
10
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855754/
13
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/29718835
14
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/26764326
15
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/23590705