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Fullscript Protocol

Cardiovascular Health – Cholesterol Support

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Protocols Fullscript Protocols
Cardiovascular Health – Cholesterol Support

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through C-quality evidence.

A
Systematic review or meta-analysis of human trials
B
RDBPC human trials
2+ studies and/or 1 study with 50 + subjects
C
RDBPC human trials
1 study

Cardiovascular Health – Cholesterol Support

Red yeast rice (Monascus purpureus)

1200-2400 mg, once per day, minimum 8 to 12 weeks1

  • Decrease in LDL, total cholesterol and homocysteine1,2,3
  • 10 mg of Monacolins K (constituent of Red yeast rice) was shown to decrease LDL-C2
  • Red Yeast Rice has been shown to be as effective as simvastatin for its capacity to lower lipids4
Red yeast rice in the Fullscript catalog

Coenzyme Q10 (CoQ10)

200 mg, once per day, minimum 3 months5

  • CoQ10 has been shown to reduce total cholesterol and LDL, and increase HDL5,6
  • Reduction in triglyceride levels observed with consistent supplementation7
Coenzyme Q10 (CoQ10) in the Fullscript catalog

Omega-3 fatty acids

2.52 g, total per day, minimum 3 months8

  • By reducing VLDL, both EPA and DHA when administered independently resulted in reduced fasting circulating triglyceride levels9
  • DHA has shown to have a greater impact in decreasing triglycerides and increasing HDL10
Omega-3 fatty acids in the Fullscript catalog

Garlic (Allium sativum)

400-600 mg, once per day, minimum 12 weeks11,12

  • Decrease in LDL (low density lipoprotein) and total cholesterol was observed 13,14,15
  • Increase in HDL (high density lipoprotein) in addition to a decrease in alipoprotein B and an increase in the LDL/alipoprotein B ratio was observed16
Garlic (Allium sativum) in the Fullscript catalog

Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

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References

1
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761143/
3
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/25897793
4
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/26956355
6
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/30296936
7
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/25913756
9
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/28797250
10
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855754/
13
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/29718835
14
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/26764326
15
Systematic review or meta-analysis of human trials
a
https://www.ncbi.nlm.nih.gov/pubmed/23590705

Fullscript content philosophy

At Fullscript, we are committed to curating accurate, and reliable educational content for practitioners and patients alike. Our educational offerings cover a broad range of topics related to integrative medicine, such as supplement ingredients, diet, lifestyle, and health conditions.

Medically reviewed by expert practitioners and our internal Integrative Medical Advisory team, all Fullscript content adheres to the following guidelines:

  1. In order to provide unbiased and transparent education, information is based on a research review and obtained from trustworthy sources, such as peer-reviewed articles and government websites. All medical statements are linked to the original reference and all sources of information are disclosed within the article.
  2. Information about supplements is always based on ingredients. No specific products are mentioned or promoted within educational content.
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  4. Resources for patients are intended to be educational and do not replace the relationship between health practitioners and patients. In all content, we clearly recommend that readers refer back to their healthcare practitioners for all health-related questions.
  5. All content is updated on a regular basis to account for new research and industry trends, and the last update date is listed at the top of every article.
  6. Potential conflicts of interest are clearly disclosed.