The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: A randomized placebo-controlled trial.

Rosa canina (Dog Rose) is a small shrub belonging to the Rosaceae family. The fresh fruit of R. canina contains vitamin C, quercetin, calcium, magnesium, iron, manganese, and zinc. In vitro studies have demonstrated that R. canina prevents the growth of Escherichia coli, the major bacteria implicated in urinary tract infections (UTIs). Researchers in Iran conducted a triple-blind, randomized, placebo-controlled trial to evaluate the preventive effect of R. canina fruit capsules against UTIs.

Methods

The study was conducted in a population of postpartum women who had undergone cesarean section because this group is at an increased risk for UTI. A total of 400 women were randomized to take R. canina capsules (500mg 2x/d) or placebo for the first 20 days post-cesarean section. R. canina was standardized to provide 0.02mg of quercetin and 0.025mg of vitamin C per 500mg of extract.

R. canina fruit capsules may reduce the risk of UTI after cesarean section.

Results

All participants had negative urine cultures before the intervention. After 7-10 days, 4 women from the intervention group and 13 from the placebo had positive asymptomatic urine cultures, most of which were due to E. coli. This statistic indicated a significantly lower risk for asymptomatic UTI in the intervention group at days 7-10 (OR = 0.22; 95% CI, 0.07-0.67; p=.006).

The total risk for UTI was also significantly reduced in the intervention group at day 20 (OR=0.32; 95% CI, 0.14-0.75; p=.008). However, there was no difference between groups in the incidence of cystitis, with 14 women from each group developing symptomatic cystitis by day 20.  

Conclusions

The authors of this study conclude that R. canina fruit capsules reduce the risk of UTI after cesarean section, with the greatest effect seen in asymptomatic bacteriuria.

Seifi, M., Abbasalizadeh, S., Mohammad-Alizadeh-Charandabi, S., Khodaie, L., & Mirghafourvand, M. (2018). The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: A randomized placebo-controlled trial. Phytotherapy Research, 32(1):76-83.