Nutrient Depletions Associated with Common Pharmaceuticals

The chart below primarily includes drug-nutrient depletions for which evidence from systematic reviews, meta-analyses, and randomized, double-blind, placebo-controlled, or randomized controlled human trials were available. The 21 pharmaceuticals included in this table are among the top-selling medications in the United States.

For an explanation of the classes of evidence, please see the Rating Scales at

Note: The information provided in this chart is based on a review of literature available at the time of publication. While the content is considered to be accurate at the time of publication, new or updated research released after the publication date may impact the accuracy of the information. Please use your discretion when using this resource. Updated: February 2020
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